製品の概要

  • 製品名L-655,240
  • 製品の詳細
    Potent thromboxane A2 receptor antagonist
  • 生理活性の詳細Potent thromboxane A2 receptor antagonist (IC50 = 7 nM). Blocks TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo. Orally active in vivo.
  • 精製度> 98%

製品の特性

  • 体系名1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid
  • 分子量373.85
  • 構造式Chemical Structure
  • 分子式C21H21ClFNO2
  • CAS 番号103253-15-2
  • 保存方法Store at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in ethanol to 50 mM and in DMSO to 50 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記ClC1=CC=C(CN2C(CC(C)(C)C(O)=O)=C(C)C3=CC(F)=CC=C32)C=C1
  • 由来

    Synthetic

  • 研究分野

    L-655,240 (ab120946) 使用論文

    This product has been referenced in:
    • Ogletree ML & Allen GT Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J Pharmacol Exp Ther 260:789-94 (1992). Read more (PubMed: 1531361) »
    • Wainwright CL & Parratt JR The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J Cardiovasc Pharmacol 12:264-71 (1988). Read more (PubMed: 2464097) »
    • Hall RA  et al. Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpro pan oic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist. Eur J Pharmacol 135:193-201 (1987). Read more (PubMed: 3582493) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"