Endogenous ionotropic / nicotinic antagonist; water soluble
生理活性の詳細Endogenous antagonist at ionotropic, glycine and α7 nicotinic receptors. Neuroprotective in vivo. Water soluble form.
Also available in simple stock solutions (ab146693) - add 1 ml of water to get an exact, ready-to-use concentration.
体系名4-Hydroxyquinoline-2-carboxylic acid sodium salt
保存方法Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
溶解性Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Grilli M et al. Modulation of the function of presynaptic alpha7 and non-alpha7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain. Br J Pharmacol149:724-32 (2006).
Read more (PubMed: 17016503) »
Pittaluga A et al. The "kynurenate test", a biochemical assay for putative cognition enhancers. J Pharmacol Exp Ther283:82-90 (1997).
Read more (PubMed: 9336311) »