Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)
Key features and details
- Endogenous ionotropic / nicotinic antagonist
- CAS Number: 492-27-3
- Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Kynurenic acid, endogenous ionotropic / nicotinic antagonist -
製品の詳細
Endogenous ionotropic / nicotinic antagonist -
生理活性の詳細
Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective in vivo. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256)
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CAS 番号
492-27-3 -
構造式
製品の特性
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体系名
4-Hydroxyquinoline-2-carboxylic acid -
分子量
189.17 -
分子式
C10H7NO3 -
PubChem 登録番号
3845 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
O=C(O)c1cc(O)c2ccccc2n1 -
由来
Synthetic
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研究分野
画像
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2D chemical structure image of ab120064, Kynurenic acid, endogenous ionotropic / nicotinic antagonist
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C1 and C2 - Inhibition of climbing fiber to Purkinje cell EPSCs in (control; black) by 1 mM Kynurenic acid (red, ab120064) or 100 nM NBQX (green, ab120045) recorded in 2.5 mM external Ca2+ at 0.05 Hz (C1) and 2 Hz (C2) stimulation frequency. D - Summary of inhibition of EPSCs by 1 mM Kynurenic acid (red, ab120064) and 100 nM NBQX (green, ab120045) in 2.5 mM external Ca2+.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (27)
ab120064 は 27 報の論文で使用されています。
- Barnes JL et al. Developmentally Transient CB1Rs on Cerebellar Afferents Suppress Afferent Input, Downstream Synaptic Excitation, and Signaling to Migrating Neurons. J Neurosci 40:6133-6145 (2020). PubMed: 32631938
- Heubl M et al. GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun 8:1776 (2017). PubMed: 29176664
- Hiu T et al. Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target. Brain 139:468-80 (2016). PubMed: 26685158
- Zarnowska ED et al. Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology 93:171-178 (2015). PubMed: 25680234
- Shin JH et al. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Proc Natl Acad Sci U S A 112:8124-9 (2015). PubMed: 26080439