製品の概要

  • 製品名Anti-Kv2.1 antibody [S39-25]
    Kv2.1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [S39-25] to Kv2.1
  • 特異性The size of the band observed in the WB analysis varies with cell background due to phosphorylation.
  • アプリケーション適用あり: ICC/IF, IHC-P, IHC-Fr, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Rabbit, Pig
  • 免疫原

    Synthetic peptide:

    LPELQSLDEFGQSTDNPQL

    , corresponding to extracellular S1-S2 loop residues 211-229 of Rat KCNB1 (NP_037318).

  • ポジティブ・コントロール
    • Rat brain lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 50% Glycerol, PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • クローン名S39-25
  • アイソタイプIgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab99011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 0.1 - 1 µg/ml. (perox) or 1 - 10 µg/ml (IF).
IHC-P Use a concentration of 0.1 - 1 µg/ml. (perox) or 1 - 10 µg/ml (IF).
IHC-Fr Use a concentration of 0.1 - 1 µg/ml. (perox) or 1 - 10 µg/ml (IF).
WB Use a concentration of 1 µg/ml. Detects a band of approximately 105-125 kDa.

ターゲット情報

  • 機能Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
  • 配列類似性Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
  • ドメインThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • 翻訳後修飾Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are all regulated by calcineurin-mediated dephosphorylation. Particularly, Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/ dephosphorylation activities. Tyr-128 can be dephosphorylated by PTPalpha and cyt-PTPepsilon. Phosphorylation levels on Ser-607 are supersensitive to neuronal activity. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5. Levels then increase to reach adult levels by P14. Phosphorylation levels on Ser-564 and Ser-607 are greatly reduced during seizures, by 40% and 85% respectively.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Delayed rectifier potassium channel 1 antibody
    • Delayed rectifier potassium channel Kv2.1 antibody
    • DRK 1 antibody
    • DRK1 antibody
    • h DRK1 K(+) channel antibody
    • h-DRK1 antibody
    • hDRK 1 antibody
    • hDRK1 antibody
    • KCB 1 antibody
    • KCB1 antibody
    • KCNB1 antibody
    • KCNB1_HUMAN antibody
    • KV2.1 antibody
    • Potassium channel protein DRK1 antibody
    • Potassium voltage gated channel shab related subfamily member 1 antibody
    • Potassium voltage-gated channel subfamily B member 1 antibody
    • Voltage-gated potassium channel subunit Kv2.1 antibody
    see all

Anti-Kv2.1 antibody [S39-25] 画像

  • Immunohistochemical detection of Kv2.1 in Mouse brain tissues using a dilution of ab99011.

Anti-Kv2.1 antibody [S39-25] (ab99011) 使用論文

ab99011 has not yet been referenced specifically in any publications.

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