Anti-Kv1.1 potassium channel 抗体 (ab94701)

製品の概要

  • 製品名Anti-Kv1.1 potassium channel antibody
    Kv1.1 potassium channel 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Kv1.1 potassium channel
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide to a region within: SIVIFCLETL PELKDDKDFT GTVHRIDNTT VIYNSNIFTD PFFIVETLCI, corresponding to internal sequence amino acids 180-229 of Human Kv1.1 potassium channel (NP_000208).

  • ポジティブ・コントロール
    • Human fetal stomach lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab94701 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • 関連疾患Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1) [MIM:160120]; also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent.
    Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1) [MIM:160120]. Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance.
  • 配列類似性Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.
  • ドメインThe N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 翻訳後修飾Palmitoylated on Cys-243; which may be required for membrane targeting.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AEMK antibody
    • EA1 antibody
    • Episodic ataxia with myokymia antibody
    • HBK1 antibody
    • HUK1 antibody
    • Kca1 1 antibody
    • Kcna1 antibody
    • KCNA1_HUMAN antibody
    • Kcpvd antibody
    • KV1.1 antibody
    • MBK1 antibody
    • mceph antibody
    • MGC124402 antibody
    • MGC126782 antibody
    • MGC138385 antibody
    • MK1 antibody
    • MK1, mouse, homolog of KV1.1 antibody
    • Potassium channel protein 1 antibody
    • Potassium voltage gated channel shaker related subfamily member 1 antibody
    • Potassium voltage gated channel subfamily A member 1 antibody
    • Potassium voltage gated channel, shaker related subfamily, member 1 (episodic ataxia with myokymia) antibody
    • Potassium voltage-gated channel subfamily A member 1 antibody
    • RBK1 antibody
    • RCK1 antibody
    • Shak antibody
    • Shaker related subfamily member 1 antibody
    • Voltage gated potassium channel subunit Kv1.1 antibody
    • Voltage-gated K(+) channel HuKI antibody
    • Voltage-gated potassium channel HBK1 antibody
    • Voltage-gated potassium channel subunit Kv1.1 antibody
    see all

Anti-Kv1.1 potassium channel antibody 画像

  • Anti-Kv1.1 potassium channel antibody (ab94701) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal stomach lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 57 kDa

Anti-Kv1.1 potassium channel antibody (ab94701) 使用論文

ab94701 has not yet been referenced specifically in any publications.

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