製品の概要

  • 製品名KT5823
  • 製品の詳細
    Potent, selective inhibitor of PKG
  • 生理活性の詳細Potent, selective, reversible inhibitor of Protein Kinase G (PKG) (Ki = 234 nM). Derivative of K252, selective over PKA and PKC (Ki values are >10 and 4 μM, respectively). Prevents increased phosphorylation of regulators of G-protein-signalling in vivo.
  • 精製度> 95%

製品の特性

  • 体系名(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
  • 分子量495.53
  • 構造式Chemical Structure
  • 分子式C29H25N3O5
  • CAS 番号126643-37-6
  • PubChem 登録番号108152
  • 保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 50 mM and in ethanol to 2.5 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記O=C(OC)[C@]8(C[C@H]7O[C@]8(C)n4c3c1n7c6ccccc6c1c2c(CN(C)C2=O)c3c5ccccc45)OC
  • 由来

    Synthetic

  • 研究分野

    KT5823 (ab120423) 使用論文

    This product has been referenced in:
    • Chan SL & Fiscus RR Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod 9:775-83 (2003). Read more (PubMed: 14614039) »
    • Burkhardt M  et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275:33536-41 (2000). Read more (PubMed: 10922374) »
    • Levander-Lindgren M ECG telemetry for pacemaker check-up. Acta Med Scand Suppl 596:72-6 (1976). Read more (PubMed: 1070230) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"