製品の概要

  • 製品名Anti-KSR1 (phospho S392) antibody
    KSR1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KSR1 (phospho S392)
  • 特異性ab52205 detects endogenous levels of KSR only when phosphorylated at serine 392.
  • アプリケーション適用あり: IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthesized phosphopeptide derived from human KSR around the phosphorylation site of serine 392 (T-E-SP-V-P).

  • ポジティブ・コントロール
    • Human brain tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab52205 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
ELISA 1/20000.

ターゲット情報

  • 機能Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Phosphorylated on Ser-309 and, to a higher extent, on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated.
  • 細胞内局在Cytoplasm. Membrane. In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BKSR 1 antibody
    • BKSR1 antibody
    • dKsr antibody
    • EK 31 antibody
    • EK31 antibody
    • hb antibody
    • Kinase suppressor of Ras 1 antibody
    • Kinase suppressor of ras antibody
    • KSR 1 antibody
    • KSR antibody
    • KSR1 antibody
    • KSR1_HUMAN antibody
    • Positive Ras signaling mediator family member (86.4 kD) antibody
    • Positive Ras signaling mediator family member antibody
    • RSU 2 antibody
    • RSU2 antibody
    • SR 31 antibody
    • SR31 antibody
    • Suppressor of activated let 60 Ras SUR3 antibody
    • Suppressor of Ras1 31 antibody
    see all

Anti-KSR1 (phospho S392) antibody 画像

  • This image shows human brain tissue stained with ab52205 at a dilution of 1/50 - 1/100. Right hand image: tissue treated with immunising peptide; left hand image: untreated.

Anti-KSR1 (phospho S392) antibody (ab52205) 使用論文

ab52205 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab52205.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"