The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 68 kDa.
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV ORF8 is a virion envelope-associated protein. Akula et al (2003) report it acts as a Glycoprotein B mediated signaling during virus entry. This Glycoprotein possesses the Arg-Gly-Asp (RGD) motif and utilizes alpha3beta1 integrin as one of the receptors for its entry into the target cells.
HHV 8 antibody
Human herpesvirus 8 antibody
Kaposi's sarcoma herpes virus antibody
Western blot - Anti-KSHV ORF8 antibody (ab36599)
All lanes : Anti-KSHV ORF8 antibody (ab36599)
Lane 1 : Uninduced BCBL-1 cell lysate Lane 2 : TPA induced BCBL-1 cell lysate Lane 3 : Purified virion
Wang X et al. Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma. PLoS Pathog13:e1006580 (2017).
Read more (PubMed: 28957431) »
Lin X et al. MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirus virions. J Virol86:12717-30 (2012).
Read more (PubMed: 22973026) »