製品の概要

  • 製品名Anti-KMT3B / NSD1 antibody
    KMT3B / NSD1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KMT3B / NSD1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    This information is considered to be commercially sensitive.

  • ポジティブ・コントロール
    • Human prostate adenocarcinoma. IHC controls: Breast carcinoma, Lung adenocarcinoma, Ovarian carcinoma, Prostate carcinoma

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IF 1/50 - 1/500.
IHC-P 1/100 - 1/500.

ターゲット情報

  • 機能Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.
  • 組織特異性Expressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung.
  • 関連疾患Defects in NSD1 are the cause of Sotos syndrome (SOTOSS) [MIM:117550]; also known as cerebral gigantism. It is a disorder characterized by excessively rapid growth, acromegalic features, and a nonprogressive cerebral disorder with mental retardation. High-arched palate and prominent jaw are noted in several patients. Most cases of Sotos syndrome are sporadic and may represent new dominant mutation.
    Defects in NSD1 are the cause of Weaver syndrome (WES) [MIM:277590]. WES is a syndrome of accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low-pitched cry, and hypertonia with camptodactyly.
    Defects in NSD1 are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
    Note=A chromosomal aberration involving NSD1 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NUP98.
    Note=A chromosomal aberration involving NSD1 is found in an adult form of myelodysplastic syndrome (MDS). Insertion of NUP98 into NSD1 generates a NUP98-NSD1 fusion product.
  • 配列類似性Belongs to the histone-lysine methyltransferase family.
    Contains 1 AWS domain.
    Contains 4 PHD-type zinc fingers.
    Contains 1 post-SET domain.
    Contains 2 PWWP domains.
    Contains 1 SET domain.
  • 細胞内局在Nucleus. Chromosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Androgen receptor coactivator 267 kDa protein antibody
    • Androgen receptor-associated protein of 267 kDa antibody
    • ARA267 antibody
    • H3 K36 HMTase antibody
    • H3-K36-HMTase antibody
    • H4 K20 HMTase antibody
    • H4-K20-HMTase antibody
    • Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antibody
    • KMT3B antibody
    • Lysine N-methyltransferase 3B antibody
    • NR binding SET domain containing protein antibody
    • NR-binding SET domain-containing protein antibody
    • Nsd1 antibody
    • NSD1_HUMAN antibody
    • Nuclear receptor binding SET domain containing protein 1 antibody
    • Nuclear receptor-binding SET domain-containing protein 1 antibody
    see all

Anti-KMT3B / NSD1 antibody 画像

  • ab84137, at a 1/250 dilution, staining KMT3B / NSD1 in formalin fixed, paraffin embedded human prostate adenocarcinoma by Immunohistochemistry.
    Detection: DAB
  • ab84137 at a 1/250 dilution,staining KMT3B/NSD1 in formalin fixed,paraffin embedded human breast carcinoma by Immunohistochemistry.

    Detection:DAB

Anti-KMT3B / NSD1 antibody (ab84137) 使用論文

ab84137 has not yet been referenced specifically in any publications.

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