Anti-KMT2G / hSET1B 抗体 (ab112049)

製品の概要

  • 製品名Anti-KMT2G / hSET1B antibody
    KMT2G / hSET1B 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KMT2G / hSET1B
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rabbit, Cow, Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region between amino acids 350-400 of KMT2G/ hSET1B (NP_055863.1).

  • ポジティブ・コントロール
    • Human Breast Carcinoma, Human Ovarian Carcinoma, and Human Testicular Seminoma tissues

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium azide
    Constituents: 99% Tris citrate/phosphate, 0.1% BSA
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab112049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

ターゲット情報

  • 機能Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
  • 配列類似性Contains 1 post-SET domain.
    Contains 1 RRM (RNA recognition motif) domain.
    Contains 1 SET domain.
  • 細胞内局在Nucleus speckle. Chromosome. Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ20803 antibody
    • Histone-lysine N-methyltransferase SETD1B antibody
    • hSET1B antibody
    • KIAA1076 antibody
    • KMT2G antibody
    • Lysine N-methyltransferase 2G antibody
    • SET domain containing 1B antibody
    • SET domain-containing protein 1B antibody
    • SET1B antibody
    • SET1B_HUMAN antibody
    • SETD1B antibody
    see all

Anti-KMT2G / hSET1B antibody 画像

  • Staining of Human KMT2G / hSET1B in a Formalin/PFA-fixed paraffin-embedded section of Human Breast Carcinoma using ab112049 at a dilution of 1/250.
  • Staining of Human KMT2G / hSET1B in a Formalin/PFA-fixed paraffin-embedded section of Human Ovarian Carcinoma using ab112049 at a dilution of 1/250.

Anti-KMT2G / hSET1B antibody (ab112049) 使用論文

ab112049 has not yet been referenced specifically in any publications.

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (HeLa)
Permeabilization Yes - 0.5% TritonX100 in PBS
Specification HeLa
Fixative Paraformaldehyde
Username

Dr. Kirk McManus

Verified customer

投稿 Aug 07 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"