This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Anti-KMT2C / MLL3 (acetyl K2809) 抗体 (ab40973)

製品の概要

  • 製品名Anti-KMT2C / MLL3 (acetyl K2809) antibody
  • 製品の詳細
    Rabbit polyclonal to KMT2C / MLL3 (acetyl K2809)

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 種交差性

    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 2800 - 2850 of Human KMT2C/ MLL3.

    (Peptide available as ab41903.)

製品の特性

アプリケーション

  • 追加情報
    This antibody gave a positive result in ELISA against the immunizing peptide (ab41903). It gave a negative result in ELISA against the non-modified equivalent peptide (ab41904). This indicates that it is specific for the modified peptide.
    See figure below.
    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.
    • 組織特異性Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
    • 配列類似性Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.
      Contains 1 A.T hook DNA-binding domain.
      Contains 1 DHHC-type zinc finger.
      Contains 6 PHD-type zinc fingers.
      Contains 1 post-SET domain.
      Contains 1 RING-type zinc finger.
      Contains 1 SET domain.
    • ドメインThe SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Histone-lysine N-methyltransferase MLL3 antibody
      • Homologous to ALR protein antibody
      • KMT2C antibody
      • Lysine N-methyltransferase 2C antibody
      • MLL3 antibody
      • MLL3_HUMAN antibody
      • Myeloid/lymphoid or mixed-lineage leukemia protein 3 antibody
      • Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog antibody
      see all

    Anti-KMT2C / MLL3 (acetyl K2809) antibody 画像

    This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.

    • This antibody gave a positive result in ELISA against the immunizing peptide (ab41903, blue). It gave a negative result in ELISA against the non-modified equivalent peptide (ab41904, yellow). This indicates that it is specific for the modified peptide.  

    Anti-KMT2C / MLL3 (acetyl K2809) antibody (ab40973) 使用論文

    ab40973 has not yet been referenced specifically in any publications.

    Product Wall

    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Human Tissue sections (Skin, Keratinocytes)
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: 1.8 mM Citrate Buffer pH = 6.0
    Permeabilization No
    Specification Skin, Keratinocytes
    Blocking step Biogenex POWER BLOCK as blocking agent for 10 minute(s) · Concentration: 10% · Temperature: 21°C
    Fixative Formaldehyde
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    投稿 Apr 27 2017

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