製品の概要

  • 製品名
  • 製品の詳細
    Chicken polyclonal to KLHL12
  • 由来種
    Chicken
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Xenopus laevis
  • 免疫原

    Synthetic peptide corresponding to Human KLHL12 aa 205-404.
    Sequence:

    KHAKKEREES LPNLLQYVRM PLLTPRYITD VIDAEPFIRC SLQCRDLVDE AKKFHLRPEL RSQMQGPRTR ARLGANEVLL VVGGFGSQQS PIDVVEKYDP KTQEWSFLPS ITRKRRYVAS VSLHDRIYVI GGYDGRSRLS SVECLDYTAD EDGVWYSVAP MNVRRGLAGA TTLGDMIYVS GGFDGSRRHT SMERYDPNID

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab14233 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500. Predicted molecular weight: 68 kDa.

ターゲット情報

  • 機能
    Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.
  • 組織特異性
    Highly expressed in testis and at lower levels in the submandibular salivary gland.
  • 配列類似性
    Contains 1 BTB (POZ) domain.
    Contains 6 Kelch repeats.
  • ドメイン
    The BTB domain is required for interaction with CUL3.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C3IP1 antibody
    • CUL3 interacting protein 1 antibody
    • CUL3-interacting protein 1 antibody
    • DKIR antibody
    • DKIR homolog antibody
    • FLJ27152 antibody
    • hDKIR antibody
    • Kelch like 12 (Drosophila) antibody
    • Kelch like 12 antibody
    • Kelch like 12 variant antibody
    • Kelch like protein 12 antibody
    • Kelch like protein C3IP1 antibody
    • kelch-like family member 12 antibody
    • Kelch-like protein 12 antibody
    • KLH12_HUMAN antibody
    • KLHL 12 antibody
    • klhl12 antibody
    • OTTHUMP00000038799 antibody
    see all

画像

  • Anti-KLHL12 antibody (ab14233) at 1/2000 dilution + E. coli derived fusion protein (KLHL12 N-205 fusion protein)

    Predicted band size: 68 kDa

プロトコール

参考文献

This product has been referenced in:
  • Angers S  et al. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol 8:348-57 (2006). Chicken . Read more (PubMed: 16547521) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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