製品の概要

  • 製品名Anti-KLHDC8B antibody
    KLHDC8B 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KLHDC8B
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide within residues: SAGGGRAFAW QVFPPMPTCR VYGTVAHQDG HLLVLGGCGR AGLPLDTAET , corresponding to N terminal amino acids 2-51 of Human KLHDC8B (NP_775817)

  • ポジティブ・コントロール
    • Human fetal stomach lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab89953 is purified by a peptide affinity chromatography method.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab89953 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 関連疾患Defects in KLHDC8B are a cause of Hodgkin lymphoma (HL) [MIM:236000]. A malignant disease characterized by progressive enlargement of the lymph nodes, spleen and general lymphoid tissue, and the presence of large, usually multinucleate, cells (Reed-Sternberg cells). Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils, eosinophils and histiocytes. Note=A chromosomal aberration disrupting KLHDC8B has been found in a family with the nodular sclerosis type of classic Hodgkin lymphoma. Translocation t(2,3)(q11.2;p21.31).
  • 配列類似性Contains 8 Kelch repeats.
  • 発生段階Transcribed predominantly during S phase, translated exclusively during mitosis and cytokinesis and rapidly degraded after cell division.
  • 細胞内局在Cytoplasm. In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ11302 antibody
    • FP17659 antibody
    • Kelch domain containing 8B antibody
    • Kelch domain containing protein 8B antibody
    • Kelch domain-containing protein 8B antibody
    • KLD8B_HUMAN antibody
    • Klhdc8b antibody
    • MGC35097 antibody
    • MGC94736 antibody
    see all

Anti-KLHDC8B antibody 画像

  • Anti-KLHDC8B antibody (ab89953) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal stomach lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

Anti-KLHDC8B antibody (ab89953) 使用論文

ab89953 has not yet been referenced specifically in any publications.

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