製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to KLF8
  • アプリケーション
    適用あり: WBmore details
  • 種交差性

    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide:

    VDMDKLINNLEVQ

    , corresponding to N terminal amino acids 2-14 of Human KLF8.

  • ポジティブ・コントロール
    • Human Kidney lysate.
  • 特記事項
    Principal Names – KLF8; Kruppel-like factor 8; BKLF3; DXS741; ZNF741; zinc finger protein 741. Official Gene Symbol - KLF8. GenBank Accession Number – NP_009181. LocusLink ID - 11279 (human)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報
    Western Blot: Approx 50kDa band seen in Human Kidney lysate.
    Predicted molecular weight: 40 kDa.
    Recommended for use at 1.0-3.0µg/ml.
  • ターゲット情報

    • 機能
      Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
    • 組織特異性
      Ubiquitous.
    • 配列類似性
      Belongs to the Sp1 C2H2-type zinc-finger protein family.
      Contains 3 C2H2-type zinc fingers.
    • 翻訳後修飾
      Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.
    • 細胞内局在
      Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Basic krueppel-like factor 3 antibody
      • BKLF3 antibody
      • DXS741 antibody
      • KLF8 antibody
      • KLF8_HUMAN antibody
      • Krueppel-like factor 8 antibody
      • Kruppel like factor 8 antibody
      • MGC138314 antibody
      • Zinc finger protein 741 antibody
      • ZNF741 antibody
      see all

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    プロトコール

    参考文献

    ab2747 has not yet been referenced specifically in any publications.

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