製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to KLF8
  • 由来種
    Goat
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Pig
  • 免疫原

    Synthetic peptide:

    VDMDKLINNLEVQ

    , corresponding to N terminal amino acids 2-14 of Human KLF8.

  • ポジティブ・コントロール
    • Human Kidney lysate.
  • 特記事項
    Principal Names – KLF8; Kruppel-like factor 8; BKLF3; DXS741; ZNF741; zinc finger protein 741. Official Gene Symbol - KLF8. GenBank Accession Number – NP_009181. LocusLink ID - 11279 (human)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Detects a band of approximately 50 kDa (predicted molecular weight: 40 kDa).

ターゲット情報

  • 機能
    Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
  • 組織特異性
    Ubiquitous.
  • 配列類似性
    Belongs to the Sp1 C2H2-type zinc-finger protein family.
    Contains 3 C2H2-type zinc fingers.
  • 翻訳後修飾
    Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Basic krueppel-like factor 3 antibody
    • BKLF3 antibody
    • DXS741 antibody
    • KLF8 antibody
    • KLF8_HUMAN antibody
    • Krueppel-like factor 8 antibody
    • Kruppel like factor 8 antibody
    • MGC138314 antibody
    • Zinc finger protein 741 antibody
    • ZNF741 antibody
    see all

画像

  • Anti-KLF8 antibody (ab2747) at 2 µg/ml + 30ug human kidney lysate

    Predicted band size: 40 kDa
    Observed band size: 50 kDa (why is the actual band size different from the predicted?)



    ab2747 staining (2µg/ml) of Human Kidney lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence.

プロトコール

参考文献

ab2747 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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