Anti-KIF5B 抗体 (ab25715)
Key features and details
- Rabbit polyclonal to KIF5B
- Suitable for: WB
- Reacts with: Human, Pig
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-KIF5B antibody
KIF5B 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to KIF5B -
由来種
Rabbit -
特異性
This antibody detects total level of endogenous kinesin protein. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human, Pig -
免疫原
Recombinant fragment corresponding to Human KIF5B. Stalk domain of human KIF5B (amino acids 331-906) expressed in E. coli (FKHC3).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.40
Preservative: 0.097% Sodium azide -
Concentration information loading...
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精製度
Protein A purified -
特記事項(精製)
Purified from rabbit serum by afinity chromatography. > 95% pure (by SDS PAGE). -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab25715の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
1/1000. Predicted molecular weight: 110 kDa.
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特記事項 |
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WB
1/1000. Predicted molecular weight: 110 kDa. |
ターゲット情報
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機能
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. -
配列類似性
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
Contains 1 kinesin motor domain. -
ドメイン
Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles. -
細胞内局在
Cytoplasm, cytoskeleton. Uniformly distributed between soma and neurites in hippocampal neurons. - Information by UniProt
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参照データベース
- Entrez Gene: 3799 Human
- Omim: 602809 Human
- SwissProt: P33176 Human
- Unigene: 327736 Human
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別名
- Conventional kinesin heavy chain antibody
- KIF 5B antibody
- KIF5B antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab25715 は 4 報の論文で使用されています。
- Furey C et al. TACC3 Regulates Microtubule Plus-End Dynamics and Cargo Transport in Interphase Cells. Cell Rep 30:269-283.e6 (2020). PubMed: 31914393
- Malikov V & Naghavi MH Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating. Cell Rep 20:2792-2799 (2017). PubMed: 28930676
- Malikov V et al. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun 6:6660 (2015). WB, ICC/IF . PubMed: 25818806
- Chu Y et al. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain 135:2058-73 (2012). ICC/IF ; Rat . PubMed: 22719003