製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to KIF20A
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within N terminal amino acids 73-229 of Human KIF20A (AAH12999)

  • ポジティブ・コントロール
    • HepG2 cell lysate, Mouse brain tissue lysate, H441 xenograft.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab104118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 100 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
  • 配列類似性
    Belongs to the kinesin-like protein family.
    Contains 1 kinesin-motor domain.
  • 翻訳後修飾
    Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.
  • 細胞内局在
    Golgi apparatus. Cytoplasm > cytoskeleton > spindle.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AA415432 antibody
    • FLJ21151 antibody
    • GG10 2 antibody
    • GG10_2 antibody
    • KI20A_HUMAN antibody
    • KIF20A antibody
    • kinesin family member 20A antibody
    • Kinesin like protein KIF20A antibody
    • Kinesin-like protein 174 antibody
    • Kinesin-like protein KIF20A antibody
    • mitotic kinesin like protein 2 antibody
    • Mitotic kinesin-like protein 2 antibody
    • MKlp2 antibody
    • OTTHUMP00000159481 antibody
    • RAB6 interacting, kinesin like (rabkinesin6) antibody
    • Rab6-interacting kinesin-like protein antibody
    • RAB6-INTERACTING PROTEIN, KINESIN-LIKE antibody
    • RAB6KIFL antibody
    • Rabkinesin 6 antibody
    • Rabkinesin-6 antibody
    see all

画像

  • Anti-KIF20A antibody (ab104118) at 1/2000 dilution + HepG2 cell lysate at 30 µg

    Predicted band size : 100 kDa
  • Anti-KIF20A antibody (ab104118) at 1/1000 dilution + Mouse brain tissue lysate at 50 µg

    Predicted band size : 100 kDa
  • Immunohistochemical analysis of paraffin-embedded H441 xenograft using ab104118 at 1/250 dilution.

参考文献

This product has been referenced in:
  • Duan J  et al. Positive expression of KIF20A indicates poor prognosis of glioma patients. Onco Targets Ther 9:6741-6749 (2016). WB, IHC ; Human . Read more (PubMed: 27843327) »
  • Khongkow P  et al. Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance. Oncogene 35:990-1002 (2016). WB . Read more (PubMed: 25961928) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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