製品の概要

  • 製品名Anti-Kidins220 antibody [P220 1F8/3]
    Kidins220 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [P220 1F8/3] to Kidins220
  • アプリケーション適用あり: WB, ELISA, IHC-P, IPmore details
  • 種交差性
    交差種: Rat
  • 免疫原

    Recombinant Kidins220/ARMS (last 347 amino acids at the carboxy terminus) protein.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab20211 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 220 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
IP Use at an assay dependent concentration.

ターゲット情報

  • 機能Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
  • 組織特異性Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
  • 配列類似性Contains 12 ANK repeats.
    Contains 1 KAP NTPase domain.
  • ドメインThe transmembrane domain mediates interaction with NTRK1.
  • 翻訳後修飾Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Ankyrin repeat-rich membrane-spanning protein antibody
    • arms antibody
    • KDIS_HUMAN antibody
    • kidins220 antibody
    • Kinase D interacting substance of 220 kDa antibody
    • Kinase D-interacting substrate of 220 kDa antibody
    • rgd 619949 antibody
    see all

Anti-Kidins220 antibody [P220 1F8/3] (ab20211) 使用論文

This product has been referenced in:
  • Deswal S  et al. Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells. J Immunol 190:1927-35 (2013). Read more (PubMed: 23359496) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"