Anti-KHDRBS3 抗体 (ab68515)
Key features and details
- Mouse polyclonal to KHDRBS3
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
製品の概要
-
製品名
Anti-KHDRBS3 antibody -
製品の詳細
Mouse polyclonal to KHDRBS3 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat, Human -
免疫原
Recombinant full length protein within Human KHDRBS3. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
-
ポジティブ・コントロール
- Rat brain tissue lysate. KHDRBS3 transfected 293T lysate.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4
Constituent: PBS -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab68515の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/500 - 1/1000. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa).
|
特記事項 |
---|
WB
1/500 - 1/1000. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa). |
ターゲット情報
-
機能
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. -
組織特異性
Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis. -
配列類似性
Belongs to the KHDRBS family.
Contains 1 KH domain. -
ドメイン
The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase. -
翻訳後修飾
Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated. -
細胞内局在
Nucleus. Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one. - Information by UniProt
-
参照データベース
- Entrez Gene: 10656 Human
- Entrez Gene: 64015 Rat
- Omim: 610421 Human
- SwissProt: O75525 Human
- SwissProt: Q9JLP1 Rat
- Unigene: 444558 Human
- Unigene: 54682 Rat
-
別名
- Etle antibody
- etoile antibody
- KH domain containing RNA binding signal transduction associated 3 antibody
see all
画像
-
Anti-KHDRBS3 antibody (ab68515) at 1/500 dilution + rat brain tissue lysate at 25 µg
Secondary
Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
Predicted band size: 39 kDa
Observed band size: 39 kDa -
All lanes : Anti-KHDRBS3 antibody (ab68515) at 1/500 dilution
Lane 1 : KHDRBS3 transfected 293T lysate
Lane 2 : Non-transfected 293T lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
Predicted band size: 39 kDa
Observed band size: 50 kDa why is the actual band size different from the predicted?
データシートおよび資料
-
Datasheet download
参考文献 (0)
ab68515 は論文での使用が確認できていません。