製品の概要

  • 製品名Anti-Keratin 12 antibody [EPR1609(2)]
    Keratin 12 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR1609(2)] to Keratin 12
  • アプリケーション適用あり: WBmore details
    適用なし: IP
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the C-terminus of Human Keratin 12 protein (Q99456).

  • ポジティブ・コントロール
    • Rat eyeball lysate.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab124975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 54 kDa.
  • 追加情報Is unsuitable for IP.
  • ターゲット情報

    • 機能May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity.
    • 組織特異性Cornea specific.
    • 関連疾患Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD) [MIM:122100]; also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
    • 配列類似性Belongs to the intermediate filament family.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CK-12 antibody
      • Cytokeratin-12 antibody
      • K12 antibody
      • K1C12_HUMAN antibody
      • Keratin 12 antibody
      • Keratin antibody
      • Keratin, type I cytoskeletal 12 antibody
      • Keratin-12 antibody
      • KRT12 antibody
      • type I cytoskeletal 12 antibody
      see all

    Anti-Keratin 12 antibody [EPR1609(2)] 画像

    • Anti-Keratin 12 antibody [EPR1609(2)] (ab124975) at 1/1000 dilution + Rat eyeball lysate at 10 µg

      Predicted band size : 54 kDa

    Anti-Keratin 12 antibody [EPR1609(2)] (ab124975) 使用論文

    This product has been referenced in:

    See 1 Publication for this product

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