Anti-KDM5C / Jarid1C / SMCX 抗体 [2E4-E1-G8] (ab106068)

製品の概要

  • 製品名Anti-KDM5C / Jarid1C / SMCX antibody [2E4-E1-G8]
    KDM5C / Jarid1C / SMCX 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2E4-E1-G8] to KDM5C / Jarid1C / SMCX
  • アプリケーション適用あり: ICC/IF, WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment corresponding to Human KDM5C/ Jarid1C/ SMCX (C terminal). Expressed in E. coli.
    Database link: P41229

  • ポジティブ・コントロール
    • 293 whole cell lysate and CEM whole cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106068 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent concentration.
WB 1/100 - 1/2000. Predicted molecular weight: 176 kDa.
ELISA 1/5000 - 1/20000.

ターゲット情報

  • 機能Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.
  • 組織特異性Expressed in all tissues examined. Highest levels found in brain and skeletal muscle.
  • 関連疾患Defects in KDM5C are the cause of mental retardation syndromic X-linked JARID1C-related (MRXSJ) [MIM:300534]. MRXSJ is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRXSJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism.
  • 配列類似性Belongs to the JARID1 histone demethylase family.
    Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 2 PHD-type zinc fingers.
  • ドメインThe first PHD-type zinc finger domain recognizes and binds H3-K9Me3.
    Both the JmjC domain and the JmjN domain are required for enzymatic activity.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DXS1272E antibody
    • Histone demethylase JARID1C antibody
    • JARID1C antibody
    • JmjC domain containing protein SMCX antibody
    • Jumonji AT rich interactive domain 1C antibody
    • Jumonji, AT rich interactive domain 1C (RBP2 like) antibody
    • Jumonji/ARID domain-containing protein 1C antibody
    • KDM5C antibody
    • KDM5C_HUMAN antibody
    • Lysine (K) specific demethylase 5C antibody
    • Lysine-specific demethylase 5C antibody
    • MRX13 antibody
    • MRXJ antibody
    • MRXSCJ antibody
    • MRXSJ antibody
    • Protein SmcX antibody
    • Protein Xe169 antibody
    • rbp2 like protein antibody
    • Selected cDNA on X antibody
    • SMCX antibody
    • Smcx homolog X chromosome antibody
    • SmcX protein antibody
    • Smcy homolog X linked antibody
    • XE169 antibody
    • Xe169 protein antibody
    see all

Anti-KDM5C / Jarid1C / SMCX antibody [2E4-E1-G8] 画像

  • Immunofluorescence image of HeLa cells using an anti-KDM5C antibody (ab106068) at a dilution of 1:150.

  • All lanes : Anti-KDM5C / Jarid1C / SMCX antibody [2E4-E1-G8] (ab106068) at 1/1000 dilution

    Lane 1 : 293 whole cell lysate
    Lane 2 : CEM whole cell lysate

    Lysates/proteins at 40 µg per lane.


    Predicted band size : 176 kDa
    Observed band size : 176 kDa

Anti-KDM5C / Jarid1C / SMCX antibody [2E4-E1-G8] (ab106068) 使用論文

ab106068 has not yet been referenced specifically in any publications.

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