Anti-KDM5B / PLU1 / Jarid1B 抗体 [JARIA3D4] (ab50775)

製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab50775 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Detects a band of approximately 45 kDa (predicted molecular weight: 190 kDa).

ターゲット情報

  • 機能Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
  • 組織特異性Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).
  • 配列類似性Belongs to the JARID1 histone demethylase family.
    Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 3 PHD-type zinc fingers.
  • ドメインBoth the JmjC domain and the JmjN domain are required for enzymatic activity.
    The 2 first PHD-type zinc finger domains are required for transcription repression activity.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cancer/testis antigen 31 antibody
    • CT31 antibody
    • Histone demethylase JARID1B antibody
    • JARID1B antibody
    • Jumonji AT rich interactive domain 1B antibody
    • Jumonji/ARID domain-containing protein 1B antibody
    • Kdm5b antibody
    • KDM5B_HUMAN antibody
    • Lysine (K) specific demethylase 5B antibody
    • Lysine demethylase 5B antibody
    • Lysine specific demethylase 5B antibody
    • Lysine-specific demethylase 5B antibody
    • PLU-1 antibody
    • PLU1 antibody
    • PPP1R98 antibody
    • Protein phosphatase 1 regulatory subunit 98 antibody
    • PUT1 antibody
    • putative DNA/chromatin binding motif antibody
    • RBBP2H1A antibody
    • RBP2 like antibody
    • RBP2-H1 antibody
    • Retinoblastoma-binding protein 2 homolog 1 antibody
    • Retinoblastoma-binding protein 2 homolog 1A antibody
    see all

Anti-KDM5B / PLU1 / Jarid1B antibody [JARIA3D4] 画像

Anti-KDM5B / PLU1 / Jarid1B antibody [JARIA3D4] (ab50775) 使用論文

ab50775 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"