製品の概要

  • 製品名
    Anti-KDM4B / JMJD2B antibody
    KDM4B / JMJD2B 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KDM4B / JMJD2B
  • アプリケーション
    適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide corresponding to Human KDM4B/ JMJD2B.
    Database link: O94953

  • ポジティブ・コントロール
    • Whole cell lysate from HeLa cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab80473 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 2-5 µg/mg of lysate.
  • 追加情報
    Is unsuitable for WB.
  • ターゲット情報

    • 機能
      Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
    • 配列類似性
      Belongs to the JHDM3 histone demethylase family.
      Contains 1 JmjC domain.
      Contains 1 JmjN domain.
      Contains 2 PHD-type zinc fingers.
      Contains 2 Tudor domains.
    • ドメイン
      The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
    • 細胞内局在
      Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • JHDM3B antibody
      • JmjC domain-containing histone demethylation protein 3B antibody
      • JMJD2B antibody
      • Jumonji domain containing 2B antibody
      • Jumonji domain containing protein 2B antibody
      • Jumonji domain-containing protein 2B antibody
      • Kdm4b antibody
      • KDM4B_HUMAN antibody
      • KIAA0876 antibody
      • Lysine (K) specific demethylase 4B antibody
      • Lysine demethylase 4B antibody
      • Lysine-specific demethylase 4B antibody
      • TDRD14B antibody
      • Tudor domain containing 14B antibody
      see all

    プロトコール

    Anti-KDM4B / JMJD2B antibody (ab80473) 使用論文

    This product has been referenced in:
    • Lu S  et al. The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2. Oncotarget 6:34704-17 (2015). WB . Read more (PubMed: 26430963) »

    See 1 Publication for this product

    Product Wall

    Thank you for contacting us.

    In regards to the homology observed between the sequence provided and the immunogen used to raise the antibodies mentioned, the highest percentage corresponds to ab91549, which shares 75% of the sequence.
    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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