Anti-KDM1 / LSD1 抗体 - ChIP Grade (ab17721)

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ab17721 は 99 報の論文で使用されています。

  • Muralidharan B  et al. LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J Neurosci 37:194-203 (2017). IP, CHIPseq ; Mouse . PubMed: 28053041
  • Sharma R  et al. Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice. Elife 6:N/A (2017). PubMed: 28262096
  • Myrick DA  et al. KDM1A/LSD1 regulates the differentiation and maintenance of spermatogonia in mice. PLoS One 12:e0177473 (2017). PubMed: 28498828
  • Zhang ZZ  et al. Long non-coding RNA LINC00628 functions as a gastric cancer suppressor via long-range modulating the expression of cell cycle related genes. Sci Rep 6:27435 (2016). WB . PubMed: 27272474
  • Sengupta A  et al. Reciprocal regulation of alternative lineages by Rgs18 and its transcriptional repressor Gfi1b. J Cell Sci 129:145-54 (2016). PubMed: 26567214
  • Schmitt AM  et al. An inducible long noncoding RNA amplifies DNA damage signaling. Nat Genet 48:1370-1376 (2016). PubMed: 27668660
  • Ancelin K  et al. Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation. Elife 5:N/A (2016). IF . PubMed: 26836306
  • Ma L  et al. miR-708/LSD1 axis regulates the proliferation and invasion of breast cancer cells. Cancer Med 5:684-92 (2016). WB . PubMed: 26833707
  • Alarcon V  et al. The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state. Sci Rep 6:25901 (2016). PubMed: 27174370
  • Wasson JA  et al. Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally. Elife 5:N/A (2016). IF, IHC . PubMed: 26814574
  • Petell CJ  et al. An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiation. Nucleic Acids Res 44:7605-17 (2016). WB, IP ; Mouse . PubMed: 27179026
  • Joo YA  et al. Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid. Biomol Ther (Seoul) 24:529-35 (2016). PubMed: 27169822
  • Zeng X  et al. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev 30:1822-36 (2016). PubMed: 27566776
  • Vasconcelos FF  et al. MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis. Cell Rep 17:469-483 (2016). ChIP, CHIPseq . PubMed: 27705795
  • Wang Y  et al. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun 7:10481 (2016). ChIP ; Mouse . PubMed: 26795843
  • Singh D  et al. Cooperative Stimulation of Megakaryocytic Differentiation by Gfi1b Gene Targets Kindlin3 and Talin1. PLoS One 11:e0164506 (2016). ChIP ; Mouse . PubMed: 27768697
  • Sun H  et al. Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch. Sci Rep 6:30903 (2016). WB . PubMed: 27481483
  • Akiyama T  et al. Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells. DNA Res 22:307-18 (2015). PubMed: 26324425
  • Grandy RA  et al. Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation. Mol Cell Biol 36:615-27 (2015). WB ; Human . PubMed: 26644406
  • Sáez JE  et al. Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation. PLoS One 10:e0131760 (2015). PubMed: 26111147
  • Joiner AM  et al. Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium. J Neurosci 35:13761-72 (2015). IHC ; Mouse . PubMed: 26446227
  • Aguilo F  et al. Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming. Cell Stem Cell 17:689-704 (2015). PubMed: 26526723
  • Laurent B  et al. A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation. Mol Cell 57:957-70 (2015). PubMed: 25684206
  • Kim YC  et al. Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2. Genome Biol 16:268 (2015). PubMed: 26634251
  • Kim YC  et al. Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity. Hepatology 62:220-31 (2015). Mouse . PubMed: 25545350
  • Cleys ER  et al. Androgen receptor and histone lysine demethylases in ovine placenta. PLoS One 10:e0117472 (2015). IP, ChIP ; Sheep . PubMed: 25675430
  • Guo Y  et al. Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation. Drug Des Devel Ther 9:3153-62 (2015). PubMed: 26124638
  • Piao L  et al. SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells. Oncotarget 6:16939-50 (2015). WB . PubMed: 26183527
  • Stadhouders R  et al. Control of developmentally primed erythroid genes by combinatorial co-repressor actions. Nat Commun 6:8893 (2015). PubMed: 26593974
  • Latos PA  et al. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Nat Commun 6:7776 (2015). WB . PubMed: 26206133
  • Ranzani V  et al. The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol 16:318-325 (2015). ChIP . PubMed: 25621826
  • Sakamoto A  et al. Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells. Cancer Res 75:1445-56 (2015). PubMed: 25649769
  • Schooley A  et al. The lysine demethylase LSD1 is required for nuclear envelope formation at the end of mitosis. J Cell Sci 128:3466-77 (2015). PubMed: 26224877
  • Miles WO  et al. The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop. Mol Cell Biol 35:4199-211 (2015). PubMed: 26438601
  • Amente S  et al. Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Oncotarget 6:14572-83 (2015). ChIP . PubMed: 26062444
  • Sankar S  et al. Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clin Cancer Res 20:4584-97 (2014). PubMed: 24963049
  • Mino K  et al. Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2). Biosci Biotechnol Biochem 78:1010-7 (2014). PubMed: 25036127
  • Barrios ÁP  et al. Differential properties of transcriptional complexes formed by the CoREST family. Mol Cell Biol 34:2760-70 (2014). PubMed: 24820421
  • Ferrari-Amorotti G  et al. Suppression of invasion and metastasis of triple-negative breast cancer lines by pharmacological or genetic inhibition of slug activity. Neoplasia 16:1047-58 (2014). PubMed: 25499218
  • Su CH  et al. An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells. Nucleic Acids Res 42:3073-88 (2014). ChIP ; Human . PubMed: 24371278
  • Yin F  et al. LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16. Mol Cell Biol 34:158-79 (2014). PubMed: 24190971
  • Seki M  et al. A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells. PLoS One 9:e95374 (2014). CHIPseq ; Mouse . PubMed: 24752154
  • Upadhyay G  et al. Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation. Proc Natl Acad Sci U S A 111:8071-6 (2014). PubMed: 24843136
  • Yokoyama A  et al. Identification of Myelin Transcription Factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific Demethylase 1 (LSD1) Complex. J Biol Chem 289:18152-18162 (2014). WB, ChIP . PubMed: 24828497
  • Ray SK  et al. CtBP and Associated LSD1 Are Required for Transcriptional Activation by NeuroD1 in Gastrointestinal Endocrine Cells. Mol Cell Biol 34:2308-2317 (2014). PubMed: 24732800
  • Liu D & Zempleni J Transcriptional regulation of the albumin gene depends on the removal of histone methylation marks by the FAD-dependent monoamine oxidase lysine-specific demethylase 1 in HepG2 human hepatocarcinoma cells. J Nutr 144:997-1001 (2014). Human . PubMed: 24744315
  • Derr RS  et al. High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients. BMC Cancer 14:604 (2014). IHC-P ; Human . PubMed: 25139823
  • Liu D & Zempleni J Low activity of LSD1 elicits a pro-inflammatory gene expression profile in riboflavin-deficient human T Lymphoma Jurkat cells. Genes Nutr 9:422 (2014). WB ; Human . PubMed: 25103574
  • Ketscher A  et al. LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6. Oncogenesis 3:e120 (2014). CHIPseq ; Human . PubMed: 25285406
  • Lin S  et al. Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. J Biol Chem 288:6238-47 (2013). PubMed: 23349461
  • Kerenyi MA  et al. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife 2:e00633 (2013). CHIPseq ; Mouse . PubMed: 23795291
  • Yakulov T  et al. Wnt3a-dependent and -independent protein interaction networks of chromatin-bound ß-catenin in mouse embryonic stem cells. Mol Cell Proteomics 12:1980-94 (2013). PubMed: 23592333
  • Pan D  et al. Suppression of gluconeogenic gene expression by LSD1-mediated histone demethylation. PLoS One 8:e66294 (2013). WB ; Mouse, Human . PubMed: 23755305
  • Maksakova IA  et al. Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells. Epigenetics Chromatin 6:15 (2013). WB . PubMed: 23735015
  • Li L  et al. Targeted disruption of hotair leads to homeotic transformation and gene derepression. Cell Rep 5:3-12 (2013). ChIP ; Mouse . PubMed: 24075995
  • Layman WS  et al. Epigenetic alterations by NuRD and PRC2 in the neonatal mouse cochlea. Hear Res 304:167-78 (2013). IHC-Fr ; Mouse . PubMed: 23911933
  • Zhang X  et al. Pluripotent stem cell protein Sox2 confers sensitivity to LSD1 inhibition in cancer cells. Cell Rep 5:445-57 (2013). ChIP ; Human . PubMed: 24139802
  • Bao J  et al. Expression profiling reveals developmentally regulated lncRNA repertoire in the mouse male germline. Biol Reprod 89:107 (2013). IP ; Mouse . PubMed: 24048575
  • Konovalov S & Garcia-Bassets I Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. J Ovarian Res 6:75 (2013). WB . PubMed: 24165091
  • Xu J  et al. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A 110:6518-23 (2013). ChIP ; Human . PubMed: 23576758
  • Ouyang H  et al. Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. PLoS One 8:e62192 (2013). ChIP . PubMed: 23626788
  • Miao F  et al. RNA-sequencing analysis of high glucose-treated monocytes reveals novel transcriptome signatures and associated epigenetic profiles. Physiol Genomics 45:287-99 (2013). ChIP ; Human . PubMed: 23386205
  • Ferrari-Amorotti G  et al. Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion. Cancer Res 73:235-45 (2013). PubMed: 23054398
  • Pollock JA  et al. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERa-dependent and -independent manners. ACS Chem Biol 7:1221-31 (2012). PubMed: 22533360
  • Okabe J  et al. Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells. Circ Res 110:1067-76 (2012). WB . PubMed: 22403242
  • Clements EG  et al. DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes. Nucleic Acids Res 40:4334-46 (2012). IP . PubMed: 22278882
  • Auriemma LB  et al. Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene. Epigenetics Chromatin 5:2 (2012). PubMed: 22240255
  • Williams JS  et al. Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens 25:812-7 (2012). PubMed: 22534796
  • Whyte WA  et al. Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature 482:221-5 (2012). PubMed: 22297846
  • Hisada K  et al. RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells. Mol Cell Biol 32:1139-49 (2012). WB ; Mouse . PubMed: 22269950
  • Le Douce V  et al. LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing. Nucleic Acids Res 40:1904-15 (2012). WB, ICC/IF, ChIP . PubMed: 22067449
  • Macfarlan TS  et al. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev 25:594-607 (2011). PubMed: 21357675
  • Cui S  et al. Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic {beta}-Type Globin Promoters in Differentiated Adult Erythroid Cells. Mol Cell Biol 31:3298-311 (2011). WB, ChIP ; Mouse . PubMed: 21670149
  • Wu CY  et al. Cryptotanshinone down-regulates androgen receptor signaling by modulating lysine-specific demethylase 1 function. Int J Cancer : (2011). PubMed: 22052438
  • Esteghamat F  et al. The DNA binding factor Hmg20b is a repressor of erythroid differentiation. Haematologica 96:1252-60 (2011). PubMed: 21606163
  • Wang Q  et al. Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res 21:1424-35 (2011). WB ; Mouse . PubMed: 21727907
  • McDonald OG  et al. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol 18:867-74 (2011). PubMed: 21725293
  • Hung T  et al. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet 43:621-9 (2011). PubMed: 21642992
  • Lee SW  et al. ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1. J Biol Chem 285:18-29 (2010). WB ; Human . PubMed: 19880879
  • Anguita E  et al. GFI1B controls its own expression binding to multiple sites. Haematologica 95:36-46 (2010). PubMed: 19773260
  • van den Berg DL  et al. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 6:369-81 (2010). PubMed: 20362541
  • Lin Y  et al. The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J : (2010). IHC-P ; Human . PubMed: 20389281
  • Rai K  et al. DNA Demethylase Activity Maintains Intestinal Cells in an Undifferentiated State Following Loss of APC. Cell 142:930-42 (2010). ChIP ; Human . PubMed: 20850014
  • Choi J  et al. Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem Biophys Res Commun 401:327-32 (2010). WB, ICC/IF, IHC-P, ChIP, IP ; Mouse . PubMed: 20833138
  • Laurent B  et al. Gfi-1B promoter remains associated with active chromatin marks throughout erythroid differentiation of human primary progenitor cells. Stem Cells 27:2153-62 (2009). WB, ChIP ; Human . PubMed: 19522008
  • Saramäki A  et al. Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1{alpha},25-Dihydroxyvitamin D3. J Biol Chem 284:8073-82 (2009). ChIP ; Human . PubMed: 19122196
  • Zhu J  et al. Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J Exp Med 206:329-41 (2009). ChIP ; Mouse . PubMed: 19188499
  • Gu H & Roizman B Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1. J Virol 83:4376-85 (2009). WB, ICC/IF, IP ; Human . PubMed: 19193804
  • Aslan JE  et al. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol Cell 34:497-509 (2009). ChIP ; Human . PubMed: 19481529
  • Turunen MP  et al. Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. Circ Res 105:604-9 (2009). ChIP . PubMed: 19696410
  • McColl G  et al. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem 283:350-7 (2008). WB ; Human . PubMed: 17959600
  • Seneda MM  et al. Developmental regulation of histone H3 methylation at lysine 4 in the porcine ovary. Reproduction 135:829-38 (2008). IHC-P ; Pig . PubMed: 18502896
  • Tsai WW  et al. p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol 28:5139-46 (2008). ChIP, IP ; Human, Mouse . PubMed: 18573881
  • Ekici M  et al. Transcription of Genes Encoding Synaptic Vesicle Proteins in Human Neural Stem Cells: CHROMATIN ACCESSIBILITY, HISTONE METHYLATION PATTERN, AND THE ESSENTIAL ROLE OF REST. J Biol Chem 283:9257-68 (2008). PubMed: 18234667
  • Godmann M  et al. Dynamic regulation of histone H3 methylation at lysine 4 in mammalian spermatogenesis. Biol Reprod 77:754-64 (2007). IHC-P ; Mouse . PubMed: 17634443
  • Scoumanne A & Chen X The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners. J Biol Chem 282:15471-5 (2007). PubMed: 17409384
  • Szewczuk LM  et al. Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry 46:6892-902 (2007). PubMed: 17511474
  • Sánchez C  et al. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics 6:820-34 (2007). PubMed: 17296600
  • Forneris F  et al. A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1. J Biol Chem 281:35289-95 (2006). PubMed: 16987819

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