製品の概要

  • 製品名Anti-KCTD11 antibody
    KCTD11 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to KCTD11
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide:

    PEVEYGRLGLQP

    by a Cysteine residue linker, corresponding to internal sequence amino acids 167-178 of Human KCTD11 (NP_001002914.1).

  • ポジティブ・コントロール
    • HEK293 lysate overexpressing Human KCTD11.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab113423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 26 kDa). Primary incubation time: 1 hour.

ターゲット情報

  • 関連性The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state.
  • 参照データベース
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Anti-KCTD11 antibody 画像

  • Lane 1 : Anti-KCTD11 antibody (ab113423) at 1 µg/ml
    Lane 2 : Anti-KCTD11 antibody (ab113423) at 1 mg/ml
    Lane 3 : anti-DYKDDDDK Tag at 1/5000 dilution

    Lane 1 : HEK293 lysate, (in RIPA buffer) overexpressing Human KCTD11 with DYKDDDDK tag at 10 µg
    Lane 2 : HEK293 lysate, Mock-transfected
    Lane 3 : HEK293 lysate, (in RIPA buffer) overexpressing Human KCTD11 with DYKDDDDK tag at 10 µg

    Developed using the ECL technique

    Predicted band size : 26 kDa

Anti-KCTD11 antibody (ab113423) 使用論文

ab113423 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"