製品の概要

  • 製品名Anti-KCNU1 antibody [S2-16]
  • 製品の詳細
    Mouse monoclonal [S2-16] to KCNU1
  • アプリケーション適用あり: WB, IHC-P, IHC-Fr, ICC/IFmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Fusion protein: DSSPSIQAQN NSTNATTPLA QGSNFFDSHH ADESHDLYPV DDTGERWSQH HHSRVYPLDT LDASDIVQEK, corresponding to amino acids 1052-1121 of Mouse KCNU1 (AAB99742).

  • ポジティブ・コントロール
    • Mouse brain lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab94586 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
IHC-Fr
ICC/IF
  • 追加情報ICC/IF: Use at a concentration of 0.1-1.0µg/mL (perox) or 1.0-10µg/mL (IF).
    IHC-P: Use at a concentration of 0.1-1.0µg/mL (perox) or 1.0-10µg/mL (IF).
    IHC-Fr: Use at a concentration of 0.1-1.0µg/mL (perox) or 1.0-10µg/mL (IF).
    WB: Use at a concentration of 1 - 10 µg/ml. Predicted molecular weight: 130 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.
    • 組織特異性Testis-specific.
    • 配列類似性Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.
      Contains 1 RCK N-terminal domain.
    • ドメインThe S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
      The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium.
      The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel.
      The C-terminal cytosolic region confers the pH-dependence.
    • 細胞内局在Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • subfamily M subunit alpha-3 antibody
      • Calcium activated potassium channel subfamily M subunit alpha 3 antibody
      • Calcium activated potassium channel subunit alpha 3 antibody
      • Calcium-activated potassium channel antibody
      • Calcium-activated potassium channel subunit alpha-3 antibody
      • KCa5 antibody
      • KCa5.1 antibody
      • Kcnma3 antibody
      • KCNMC1 antibody
      • KCNU 1 antibody
      • KCNU1 antibody
      • KCNU1_HUMAN antibody
      • Potassium channel subfamily U member 1 antibody
      • Slo3 antibody
      • Slowpoke homolog 3 antibody
      see all

    Anti-KCNU1 antibody [S2-16] 画像



    • Predicted band size : 130 kDa
      Western blot detection of KCNU1 in Rat brain membrane lysates using ab94586 at 1:1000 dilution.

    Anti-KCNU1 antibody [S2-16] (ab94586) 使用論文

    ab94586 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab94586.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"