製品の概要

  • 製品名Anti-KCNQ3 (phospho T246) antibody
    KCNQ3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KCNQ3 (phospho T246)
  • 特異性ab62456 detects endogenous levels of KCNQ3 only when phosphorylated at threonine 246.
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide derived from human KCNQ3 around the phosphorylation site of threonine 246 (G-G-TP-W-K).

  • ポジティブ・コントロール
    • Human brain tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab62456 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non phosphopeptide was removed by chromatography using non phosphopeptide corresponding to the phosphorylation site.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab62456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/20000.
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
  • 組織特異性Predominantly expressed in brain.
  • 関連疾患Defects in KCNQ3 are the cause of benign neonatal epilepsy type 2 (EBN2) [MIM:121201]. Benign neonatal epilepsy is characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset.
  • 配列類似性Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.
  • ドメインThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BFNC 2 antibody
    • BFNC antibody
    • BFNC2 antibody
    • EBN 2 antibody
    • EBN2 antibody
    • KCNQ 3 antibody
    • KCNQ3 antibody
    • KCNQ3_HUMAN antibody
    • KQT like 3 antibody
    • KQT-like 3 antibody
    • KV7.3 antibody
    • Potassium channel subunit alpha KvLQT3 antibody
    • Potassium channel voltage gated subfamily Q member 3 antibody
    • Potassium voltage gated channel KQT like protein 3 antibody
    • Potassium voltage gated channel KQT like subfamily member 3 antibody
    • Potassium voltage gated channel subfamily KQT member 3 antibody
    • Potassium voltage-gated channel subfamily KQT member 3 antibody
    • Voltage gated potassium channel subunit Kv7.3 antibody
    • Voltage-gated potassium channel subunit Kv7.3 antibody
    see all

Anti-KCNQ3 (phospho T246) antibody 画像

  • ab62456, at 1/50 dilution, staining KCNQ3 in paraffin embedded human brain tissue by Immunohistochemistry in the absence or presence of the immunising peptide.

Anti-KCNQ3 (phospho T246) antibody (ab62456) 使用論文

ab62456 has not yet been referenced specifically in any publications.

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