製品の概要

  • 製品名Anti-KCNMB4 antibody
    KCNMB4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KCNMB4
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Sheep, Rabbit, Guinea pig, Cow, Cat, Pig
  • 免疫原

    Synthetic peptide designed within residues: CGADCRGTSQ YPCVQVYVNN SESNSRALLH SDEHQLLTNP KCSYIPPCKR, corresponding to internal sequence amino acids 72-121 of Human KCNMB4 (NP_055320)

  • ポジティブ・コントロール
    • THP1 cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab89703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 24 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
  • 組織特異性Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.
  • 配列類似性Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily.
  • ドメインResistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.
  • 翻訳後修飾Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics.
    N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BK channel subunit beta 4 antibody
    • BK channel subunit beta-4 antibody
    • BKbeta4 antibody
    • Calcium activated potassium channel beta 4 subunit antibody
    • Calcium activated potassium channel subfamily M subunit beta 4 antibody
    • Calcium activated potassium channel subunit beta 4 antibody
    • Calcium-activated potassium channel antibody
    • Calcium-activated potassium channel subunit beta-4 antibody
    • Charybdotoxin receptor subunit beta 4 antibody
    • Charybdotoxin receptor subunit beta-4 antibody
    • Hbeta4 antibody
    • K(VCA)beta 4 antibody
    • K(VCA)beta-4 antibody
    • KCMB4_HUMAN antibody
    • KCNMB 4 antibody
    • Kcnmb4 antibody
    • Large conductance calcium dependent potassium ion channel beta 4 subunit antibody
    • Maxi K channel subunit beta 4 antibody
    • Maxi K channel subunit beta-4 antibody
    • Potassium large conductance calcium activated channel subfamily M beta member 4 antibody
    • Slo beta 4 antibody
    • Slo-beta-4 antibody
    • subfamily M subunit beta-4 antibody
    see all

Anti-KCNMB4 antibody 画像

  • Anti-KCNMB4 antibody (ab89703) at 1 µg/ml + THP1 cell lysate at 10 µg

    Secondary
    HRP-conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 24 kDa

Anti-KCNMB4 antibody (ab89703) 使用論文

This product has been referenced in:
  • Yang J  et al. Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma. J Hematol Oncol 7:76 (2014). WB, IHC ; Human . Read more (PubMed: 25300797) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab89703.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"