Anti-KCNJ1 (phospho S44/25) 抗体 (ab111489)


  • 製品名Anti-KCNJ1 (phospho S44/25) antibody
    KCNJ1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KCNJ1 (phospho S44/25)
  • 特異性ab111489 detects endogenous levels of KCNJ1 only when phosphorylated at serine 44/25 (Human: Ser44; Mouse: Ser25; Rat: Ser44).
  • アプリケーション適用あり: IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide derived from Human KCNJ1 around the phosphorylation site of serine 44/25 (L-V-SP-K-D).

  • ポジティブ・コントロール
    • A549 cells; Human brain tissue.


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 49% PBS, 0.88% Sodium chloride
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab111489 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野


Our Abpromise guarantee covers the use of ab111489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.


  • 機能In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
  • 組織特異性In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.
  • 関連疾患Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) [MIM:241200]; also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
  • 配列類似性Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ATP regulated potassium channel ROM K antibody
    • ATP sensitive inward rectifier potassium channel 1 antibody
    • ATP-regulated potassium channel ROM-K antibody
    • ATP-sensitive inward rectifier potassium channel 1 antibody
    • Inward rectifier K(+) channel Kir1.1 antibody
    • inwardly rectifying K+ channel antibody
    • inwardly rectifying subfamily J member 1 antibody
    • IRK1_HUMAN antibody
    • KCNJ 1 antibody
    • KCNJ antibody
    • Kcnj1 antibody
    • Kir 1.1 antibody
    • Kir1.1 antibody
    • OTTHUMP00000045938 antibody
    • Potassium channel antibody
    • Potassium channel inwardly rectifying subfamily J member 1 antibody
    • potassium inwardly-rectifying channel J1 antibody
    • ROMK 1 antibody
    • ROMK 2 antibody
    • ROMK antibody
    • ROMK1 antibody
    • ROMK2 antibody
    see all

Anti-KCNJ1 (phospho S44/25) antibody 画像

  • ab111489, at 1/50 dilution, staining KCNJ1 in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.
  • ab111489, at 1/100 dilution, staining KCNJ1 in A549 cells by Immunofluorescence, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-KCNJ1 (phospho S44/25) antibody (ab111489) 使用論文

ab111489 has not yet been referenced specifically in any publications.

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