製品の概要

  • 製品名Anti-KCNJ1 antibody
    KCNJ1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KCNJ1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 216-265 (LRKSLLIGSH IYGKLLKTTV TPEGETIILD QININFVVDA GNENLFFISP) of Human KCNJ1 (NP_000211).

  • ポジティブ・コントロール
    • HepG2 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab85479 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
  • 組織特異性In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.
  • 関連疾患Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) [MIM:241200]; also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
  • 配列類似性Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ATP regulated potassium channel ROM K antibody
    • ATP sensitive inward rectifier potassium channel 1 antibody
    • ATP-regulated potassium channel ROM-K antibody
    • ATP-sensitive inward rectifier potassium channel 1 antibody
    • Inward rectifier K(+) channel Kir1.1 antibody
    • inwardly rectifying K+ channel antibody
    • inwardly rectifying subfamily J member 1 antibody
    • IRK1_HUMAN antibody
    • KCNJ 1 antibody
    • KCNJ antibody
    • Kcnj1 antibody
    • Kir 1.1 antibody
    • Kir1.1 antibody
    • OTTHUMP00000045938 antibody
    • Potassium channel antibody
    • Potassium channel inwardly rectifying subfamily J member 1 antibody
    • potassium inwardly-rectifying channel J1 antibody
    • ROMK 1 antibody
    • ROMK 2 antibody
    • ROMK antibody
    • ROMK1 antibody
    • ROMK2 antibody
    see all

Anti-KCNJ1 antibody 画像

  • Anti-KCNJ1 antibody (ab85479) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 45 kDa
    Observed band size : 45 kDa

Anti-KCNJ1 antibody (ab85479) 使用論文

ab85479 has not yet been referenced specifically in any publications.

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