製品の概要

  • 製品名Anti-KCNC3 antibody
    KCNC3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KCNC3
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Guinea pig, Cow, Cat
  • 免疫原

    Synthetic peptide corresponding to a region within the internal sequence amino acids 468-517 (YAERIGADPD DILGSNHTYF KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM) of human KCNC3 (NP_004968).

  • ポジティブ・コントロール
    • 293T cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified by peptide affinity chromatography method.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab83556 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay, 1/62500.

WB Use a concentration of 1 µg/ml. Predicted molecular weight: 81 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • 関連疾患Defects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13) [MIM:605259]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients.
  • 配列類似性Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.
  • ドメインThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Kcnc3 antibody
    • KCNC3_HUMAN antibody
    • KSHIIID antibody
    • KV3.3 antibody
    • Potassium voltage gated channel Shaw related subfamily member 3 antibody
    • Potassium voltage gated channel subfamily C member 3 antibody
    • Potassium voltage-gated channel subfamily C member 3 antibody
    • SCA13 antibody
    • Shaw related subfamily, member 3 antibody
    • Shaw related voltage gated potassium channel protein 3 antibody
    • Spinocerebellar ataxia 13 antibody
    • Voltage gated potassium channel protein KV3.3 antibody
    • Voltage gated potassium channel subunit Kv3.3 antibody
    • Voltage-gated potassium channel subunit Kv3.3 antibody
    see all

Anti-KCNC3 antibody 画像



  • Predicted band size : 81 kDa
    Western blot analysis of Human fetal lung tissue lysate labeling KCNC3 with ab83556 at 1.0µg/ml.
  • Anti-KCNC3 antibody (ab83556) at 1 µg/ml + 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 81 kDa
    Observed band size : 81 kDa
    Gel concentration 12%

Anti-KCNC3 antibody (ab83556) 使用論文

ab83556 has not yet been referenced specifically in any publications.

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