製品の概要
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製品名Anti-KCNC1 (phospho S503) antibody
KCNC1 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to KCNC1 (phospho S503)
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特異性Specific for KCNC1 phosphorylated at S503.
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アプリケーション適用あり: WB, IHC-Frmore details
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種交差性交差種: Mouse, Rat
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免疫原
Phosphopeptide corresponding to amino acid residues surrounding the phosphorylated S503 of rat KCNC1, conjugated to KLH (keyhole limpet haemocyanin).
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ポジティブ･コントロール
- Rat brain
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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バッファーPreservative: None
Constituents: 50% Glycerol, 100µg/ml BSA, 150mM Sodium chloride, 10mM HEPES. pH 7.5 -
Concentration information loading... -
精製度Immunogen affinity purified
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特記事項（精製）Purified from rabbit serum by sequential phospho- and dephosphopeptide affinity columns.
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab30566 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/1000. Detects a band of approximately 100 kDa (predicted molecular weight: 66 kDa). | |
| IHC-Fr | 1/1000. |
ターゲット情報
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機能Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
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関連疾患Epilepsy, progressive myoclonic 7
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配列類似性Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
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ドメインThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. -
細胞内局在Cell membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 16502 Mouse
- Entrez Gene: 25327 Rat
- SwissProt: P15388 Mouse
- SwissProt: P25122 Rat
- Unigene: 249386 Mouse
- Unigene: 33095 Rat
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別名
- C230009H10Rik antibody
- FLJ41162 antibody
- FLJ42249 antibody
see all
Anti-KCNC1 (phospho S503) antibody 画像
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Immunohistochemistry - KCNC1 (phospho S503) antibody (ab30566)Staining of rat medial nucleus of the trapezoid body (MNTB) cells with ab30566 (1/1000 dilution).
Left - control cells. Right - cells that have been exposed to protein kinase C activator PMA.
Anti-KCNC1 (phospho S503) antibody (ab30566) 使用論文
ab30566 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"