製品の概要

  • 製品名Anti-KCNA5 antibody
    KCNA5 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KCNA5
  • 特異性ab110469 detects endogenous levels of total KCNA5 protein.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from an internal region of Human KCNA5 (UniProt ID: P22460).

  • ポジティブ・コントロール
    • Extracts from 293 cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110469 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 67 kDa.

ターゲット情報

  • 機能Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
  • 組織特異性Pancreatic islets and insulinoma.
  • 関連疾患Defects in KCNA5 are the cause of atrial fibrillation familial type 7 (ATFB7) [MIM:612240]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.
  • 配列類似性Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
  • ドメインThe amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 翻訳後修飾Sumoylated on Lys-221, and Lys-536, preferentially by SUMO3. Sumoylation regulates the voltage sensitivity of the channel.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ATFB7 antibody
    • cardiac potassium channel antibody
    • HCK1 antibody
    • HK2 antibody
    • HPCN1 antibody
    • insulinoma and islet potassium channel antibody
    • KCNA5 antibody
    • KCNA5_HUMAN antibody
    • KV1.5 antibody
    • PCN1 antibody
    • potassium channel 1 antibody
    • Potassium channel, insulinoma and islet cell antibody
    • Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody
    • Potassium voltage gated channel subfamily A member 5 antibody
    • Potassium voltage-gated channel subfamily A member 5 antibody
    • Voltage-gated potassium channel HK2 antibody
    • voltage-gated potassium channel protein Kv1.5 antibody
    • Voltage-gated potassium channel subunit Kv1.5 antibody
    see all

Anti-KCNA5 antibody 画像

  • All lanes : Anti-KCNA5 antibody (ab110469) at 1/500 dilution

    Lane 1 : Extracts from 293 cells
    Lane 2 : Extracts from 293 cells, treated with synthesized peptide

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 67 kDa

Anti-KCNA5 antibody (ab110469) 使用論文

ab110469 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab110469.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"