Potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = ~0.32 μM in guinea pig ventricular cells). Also potent blocker of TRPC channels (IC50 values are 0.46, 0.71 and 1.38 μM at TRPC3, TRPC6 and TRPC5, respectively).
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Elias CL et al. Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences. Am J Physiol Heart Circ Physiol281:H1334-45 (2001).
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Iwamoto T et al. A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1. J Biol Chem271:22391-7 (1996).
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Watano T et al. A novel antagonist, No. 7943, of the Na+/Ca2+ exchange current in guinea-pig cardiac ventricular cells. Br J Pharmacol119:555-63 (1996).
Read more (PubMed: 8894178) »