製品の概要
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製品名Anti-KAT6B / MORF antibody
KAT6B / MORF 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to KAT6B / MORF
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由来種Rabbit
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特異性This antibody reacts with MORF and MORF alpha.
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アプリケーション適用あり: WB, IHC-P, IPmore details
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種交差性交差種: Cow, Human
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免疫原
Synthetic peptide corresponding to Cow KAT6B/ MORF (N terminal) conjugated to keyhole limpet haemocyanin.
Database link: A7E390
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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バッファーPreservative: None
Constituents: PBS, pH 7.4 -
Concentration information loading... -
精製度Protein A purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab58823 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/7500. Detects a band of approximately 230 kDa (predicted molecular weight: 231 kDa). | |
| IHC-P | 1/1000. | |
| IP | Use at an assay dependent concentration. |
ターゲット情報
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機能Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
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組織特異性Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary.
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関連疾患Note=A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP.
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配列類似性Belongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger.
Contains 1 H15 (linker histone H1/H5 globular) domain.
Contains 2 PHD-type zinc fingers. -
ドメインThe N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
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翻訳後修飾Autoacetylated.
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細胞内局在Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 23522 Human
- Omim: 605880 Human
- SwissProt: A7E390 Cow
- SwissProt: Q8WYB5 Human
- Unigene: 35758 Human
- Unigene: 599543 Human
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別名
- DKFZp313G1618 antibody
- FLJ90335 antibody
- Histone acetyltransferase MORF antibody
see all
参考文献
This product has been referenced in:
- Simpson MA et al. De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome. Am J Hum Genet 90:290-4 (2012). WB . Read more (PubMed: 22265017) »
- Kraft M et al. Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice. J Clin Invest 121:3479-91 (2011). WB ; Human . Read more (PubMed: 21804188) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"