製品の概要

  • 製品名Anti-KAT13D / CLOCK antibody
    KAT13D / CLOCK 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KAT13D / CLOCK
  • アプリケーション適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Sheep, Horse, Cow, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 450-500 of Human KAT13D/ CLOCK (NP_004889.1)

  • ポジティブ・コントロール
    • HeLa whole cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab93805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP
  • 追加情報IP: Use at a concentration of 2-5 µg/ml.


    Is unsuitable for WB.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate: ARNTL.
    • 組織特異性Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN).
    • 配列類似性Contains 1 basic helix-loop-helix (bHLH) domain.
      Contains 1 PAC (PAS-associated C-terminal) domain.
      Contains 2 PAS (PER-ARNT-SIM) domains.
    • 翻訳後修飾Phosphorylation is dependent on CLOCK-ARNTL heterodimer formation.
    • 細胞内局在Cytoplasm. Nucleus. Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL-dependent. Phosphorylated form located in the nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • bHLHe8 antibody
      • Circadian locomoter output cycles kaput protein antibody
      • Circadian locomoter output cycles protein kaput antibody
      • Circadian Locomotor Output Cycles Kaput antibody
      • Circadium Locomotor Output Cycles Kaput antibody
      • Class E basic helix-loop-helix protein 8 antibody
      • CLOCK antibody
      • Clock circadian regulator antibody
      • Clock homolog antibody
      • Clock protein antibody
      • CLOCK_HUMAN antibody
      • hCLOCK antibody
      • KIAA0334 antibody
      see all

    Anti-KAT13D / CLOCK antibody 画像

    • ab93805 at 1 µg/ml detecting KAT13D/CLOCK in HeLa whole cell lysate by WB following IP.
      Lane 1: ab93805 at 3µg/mg of lysate
      Lane 2: IP with an antibody which recognizes an downstream epitope of KAT13D/CLOCK
      Lane 3: control IgG.
      In each case, 1 mg of lysate was used for IP and 20% of the IP was loaded.
      Detection: Chemiluminescence with an exposure time of 30 seconds

    Anti-KAT13D / CLOCK antibody (ab93805) 使用論文

    ab93805 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"