製品の概要

  • 製品名Anti-KAT13D / CLOCK antibody
    KAT13D / CLOCK 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KAT13D / CLOCK
  • 特異性ab65033 detects endogenous levels of total KAT13D / CLOCK protein.
  • アプリケーション適用あり: ELISA, IHC-P, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from an internal sequence of human KAT13D/ CLOCK

  • ポジティブ・コントロール
    • IHC-P: Human skeletal muscle tissue. WB: HUVEC cell extracts.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab65033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/20000.
IHC-P 1/50 - 1/100.
WB 1/500 - 1/1000. Detects a band of approximately 95 kDa (predicted molecular weight: 95 kDa).

ターゲット情報

  • 機能ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate: ARNTL.
  • 組織特異性Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN).
  • 配列類似性Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.
  • 翻訳後修飾Phosphorylation is dependent on CLOCK-ARNTL heterodimer formation.
  • 細胞内局在Cytoplasm. Nucleus. Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL-dependent. Phosphorylated form located in the nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bHLHe8 antibody
    • Circadian locomoter output cycles kaput protein antibody
    • Circadian locomoter output cycles protein kaput antibody
    • Circadian Locomotor Output Cycles Kaput antibody
    • Circadium Locomotor Output Cycles Kaput antibody
    • Class E basic helix-loop-helix protein 8 antibody
    • CLOCK antibody
    • Clock circadian regulator antibody
    • Clock homolog antibody
    • Clock protein antibody
    • CLOCK_HUMAN antibody
    • hCLOCK antibody
    • KIAA0334 antibody
    see all

Anti-KAT13D / CLOCK antibody 画像

  • ab65033, at a 1/50 dilution, staining KAT13D / CLOCK in paraffin embedded human skeletal muscle tissue by Immunohistochemistry in the absence or presence of the immunising peptide.
  • All lanes : Anti-KAT13D / CLOCK antibody (ab65033) at 1/500 dilution

    Lane 1 : HUVEC cell extract
    Lane 2 : HUVEC cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 95 kDa
    Observed band size : 95 kDa

Anti-KAT13D / CLOCK antibody (ab65033) 使用論文

This product has been referenced in:
  • Lengyel Z  et al. Circadian clocks and tumor biology: what is to learn from human skin biopsies? Gen Comp Endocrinol 188:67-74 (2013). Read more (PubMed: 23608545) »
  • Nagalla S  et al. Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity. Blood 117:5189-97 (2011). WB ; Human . Read more (PubMed: 21415270) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"