製品の概要

  • 製品名Anti-KAT13C / NCOA2 antibody
    KAT13C / NCOA2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KAT13C / NCOA2
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region within residues 1400 and the C terminus (1464) of human KAT13C/ NCOA2 (NP_006531.1).

  • ポジティブ・コントロール
    • Human breast adenocarcinoma; human prostate adenocarcinoma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84140 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500.
    Epitope exposure is recommended.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.
    • 関連疾患Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
    • 配列類似性Belongs to the SRC/p160 nuclear receptor coactivator family.
      Contains 1 bHLH (basic helix-loop-helix) domain.
      Contains 1 PAS (PER-ARNT-SIM) domain.
    • ドメインContains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
      The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
      Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • bHLHe75 antibody
      • Class E basic helix-loop-helix protein 75 antibody
      • glucocorticoid receptor interacting protein 1 antibody
      • GRIP 1 antibody
      • GRIP1 antibody
      • hTIF2 antibody
      • MED1 antibody
      • MGC138808 antibody
      • NCoA 2 antibody
      • NCoA-2 antibody
      • Ncoa2 antibody
      • NCOA2_HUMAN antibody
      • Nuclear receptor coactivator 2 antibody
      • Oncogene FGR antibody
      • p160 antibody
      • SRC 2 antibody
      • src2 antibody
      • Steroid receptor coactivator 2 antibody
      • TIF 2 antibody
      • TIF2 antibody
      • Transcriptional intermediary factor 2 antibody
      see all

    Anti-KAT13C / NCOA2 antibody 画像

    • ab84140, at a 1/250 dilution, staining KAT13C / NCOA2 in formalin fixed, paraffin embedded human breast adenocarcinoma tissue by Immunohistochemistry.
      Detection: DAB
    • ab84140, at a 1/100 dilution, staining KAT13C / NCOA2 in formalin fixed, paraffin embedded human prostate adenocarcinoma by Immunohistochemistry.
      Detection: DAB

    Anti-KAT13C / NCOA2 antibody (ab84140) 使用論文

    ab84140 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab84140.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"