製品の概要

  • 製品名Anti-KAT13C / NCOA2 antibody
    KAT13C / NCOA2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KAT13C / NCOA2
  • アプリケーション適用あり: ICC/IF, ICC, IPmore details
    適用なし: WB
  • 種交差性
    交差種: Rat, Hamster, Human
    交差が予測される動物種: Mouse, Non Human Primates
  • 免疫原

    Synthetic peptide corresponding to Human KAT13C/ NCOA2 aa 206-217.
    Sequence:

    PLPDSEEEGHDS


    (Peptide available as ab4917)

  • ポジティブ・コントロール
    • CHO cells
  • 特記事項

     

     

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab2842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF 1/1000.
ICC 1/1000.
IP Use at an assay dependent concentration.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.
    • 関連疾患Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
    • 配列類似性Belongs to the SRC/p160 nuclear receptor coactivator family.
      Contains 1 bHLH (basic helix-loop-helix) domain.
      Contains 1 PAS (PER-ARNT-SIM) domain.
    • ドメインContains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
      The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
      Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • bHLHe75 antibody
      • Class E basic helix-loop-helix protein 75 antibody
      • glucocorticoid receptor interacting protein 1 antibody
      • GRIP 1 antibody
      • GRIP1 antibody
      • hTIF2 antibody
      • MED1 antibody
      • MGC138808 antibody
      • NCoA 2 antibody
      • NCoA-2 antibody
      • Ncoa2 antibody
      • NCOA2_HUMAN antibody
      • Nuclear receptor coactivator 2 antibody
      • Oncogene FGR antibody
      • p160 antibody
      • SRC 2 antibody
      • src2 antibody
      • Steroid receptor coactivator 2 antibody
      • TIF 2 antibody
      • TIF2 antibody
      • Transcriptional intermediary factor 2 antibody
      see all

    Anti-KAT13C / NCOA2 antibody 画像

    • Immunolocalization of KAT13C/NCOA2 in CHO cells using ab2842.

    Anti-KAT13C / NCOA2 antibody (ab2842) 使用論文

    ab2842 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"