Anti-KAT13A / SRC1 抗体 (ab5407)


  • 製品名Anti-KAT13A / SRC1 antibody
    KAT13A / SRC1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to KAT13A / SRC1
  • アプリケーション適用あり: WB, IHC-P, IPmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to Human KAT13A/ SRC1 aa 600-650.
    Database link: Q15788


Our Abpromise guarantee covers the use of ab5407 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000 - 1/10000.
IHC-P 1/500 - 1/2000.
IP Use at 2-10 µg/mg of lysate.


  • 機能Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
  • 組織特異性Widely expressed.
  • 関連疾患Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
  • 配列類似性Belongs to the SRC/p160 nuclear receptor coactivator family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • ドメインThe C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity.
    Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.
  • 翻訳後修飾Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.
    Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bHLHe74 antibody
    • Class E basic helix-loop-helix protein 74 antibody
    • F SRC 1 antibody
    • Hin 2 protein antibody
    • Hin2 protein antibody
    • MGC129719 antibody
    • MGC129720 antibody
    • mNRC 1 antibody
    • NCoA 1 antibody
    • NCoA-1 antibody
    • Ncoa1 antibody
    • NCOA1_HUMAN antibody
    • Nuclear receptor coactivator 1 antibody
    • Nuclear receptor coactivator protein 1 antibody
    • NY REN 52 antigen antibody
    • Protein Hin 2 antibody
    • Protein Hin-2 antibody
    • Protein Hin2 antibody
    • Renal carcinoma antigen NY REN 52 antibody
    • Renal carcinoma antigen NY-REN-52 antibody
    • RIP 160 antibody
    • RIP160 antibody
    • SRC 1 antibody
    • SRC-1 antibody
    • Steroid receptor coactivator 1 antibody
    see all

Anti-KAT13A / SRC1 antibody 画像

  • All lanes : Anti-KAT13A / SRC1 antibody (ab5407) at 0.1 µg/ml

    Lane 1 : 293T whole cell lysate at 50 µg
    Lane 2 : 293T whole cell lysate at 15 µg
    Lane 3 : 293T whole cell lysate at 5 µg
    Lane 4 : HeLa cells at 50 µg
    Lane 5 : Mouse NIH3T3 cells at 50 µg


    Exposure time:30 seconds

  • KAT13A/SRC1  was immunoprecipitated from 1mg of 293T cells prepared using NETN lysis buffer.

    Exposure time: 10 seconds.

  • Immunohistochemical analysis of paraffin-embedded Human prostate carcinoma labeling KAT13A/SRC1 with ab5407 at 1/1000 dilution.

    Detection: DAB.

    Counter stained with Hematoxylin.

Anti-KAT13A / SRC1 antibody (ab5407) 使用論文

ab5407 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

I am not sure if you intend to send this email to Abcam however we can offer the following products


ab2859; http://...

Read More
Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunoprecipitation
Sample Human Tissue lysate - nuclear (huh-7)
Total protein in input 1e+006 cells
Specification huh-7
Treatment cells expressing recombitant protein
Immuno-precipitation step Protein A

Abcam user community

Verified customer

投稿 Aug 23 2009

The peptide comes from upstream of aa 627. It is not contained within aa 627 to 786 according to Q15788 (Swiss-Prot entry). If you have any additional questions, please contact us again.