Anti-KAT13A / SRC1 抗体 [3532C6a] (ab67101)

製品の概要

  • 製品名Anti-KAT13A / SRC1 antibody [3532C6a]
    KAT13A / SRC1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [3532C6a] to KAT13A / SRC1
  • アプリケーション適用あり: WB, Dot blotmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment corresponding to Human KAT13A/ SRC1 (internal sequence).
    Database link: Q15788

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab67101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
Dot blot
  • 追加情報Dot: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Detects a band of approximately 37 kDa (predicted molecular weight of full length protein: 160 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
    • 組織特異性Widely expressed.
    • 関連疾患Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
    • 配列類似性Belongs to the SRC/p160 nuclear receptor coactivator family.
      Contains 1 basic helix-loop-helix (bHLH) domain.
      Contains 1 PAS (PER-ARNT-SIM) domain.
    • ドメインThe C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity.
      Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.
    • 翻訳後修飾Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.
      Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • bHLHe74 antibody
      • Class E basic helix-loop-helix protein 74 antibody
      • F SRC 1 antibody
      • Hin 2 protein antibody
      • Hin2 protein antibody
      • MGC129719 antibody
      • MGC129720 antibody
      • mNRC 1 antibody
      • NCoA 1 antibody
      • NCoA-1 antibody
      • Ncoa1 antibody
      • NCOA1_HUMAN antibody
      • Nuclear receptor coactivator 1 antibody
      • Nuclear receptor coactivator protein 1 antibody
      • NY REN 52 antigen antibody
      • Protein Hin 2 antibody
      • Protein Hin-2 antibody
      • Protein Hin2 antibody
      • Renal carcinoma antigen NY REN 52 antibody
      • Renal carcinoma antigen NY-REN-52 antibody
      • RIP 160 antibody
      • RIP160 antibody
      • SRC 1 antibody
      • SRC-1 antibody
      • Steroid receptor coactivator 1 antibody
      see all

    Anti-KAT13A / SRC1 antibody [3532C6a] 画像

    • Anti-KAT13A / SRC1 antibody [3532C6a] (ab67101) + immunising recombinant fragment

      Predicted band size : 160 kDa
      Observed band size : 37 kDa (why is the actual band size different from the predicted?)

      Western blot analysis of immunized recombinant protein using anti-NCOA1 monoclonal antibody

    Anti-KAT13A / SRC1 antibody [3532C6a] (ab67101) 使用論文

    ab67101 has not yet been referenced specifically in any publications.

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