製品の概要

  • 製品名Anti-Kallikrein 6 antibody
    Kallikrein 6 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Kallikrein 6
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Cow
  • 免疫原

    Synthetic peptide:

    KEKPGVYTDVCTHIR

    , corresponding to C terminal amino acids 228-242 of Mouse Kallikrein 6 (NP_035307.1)

  • ポジティブ・コントロール
    • Mouse Liver lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab109295 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 27 kDa).

ターゲット情報

  • 機能Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
  • 組織特異性In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
  • 配列類似性Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • 翻訳後修飾Inactivated by autolytic cleavage after Arg-80.
  • 細胞内局在Secreted. Nucleus > nucleolus. Cytoplasm. Mitochondrion. Microsome. In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Bssp antibody
    • hK 6 antibody
    • hK6 antibody
    • Kallikrein 6 precursor antibody
    • Kallikrein related peptidase 6 antibody
    • Kallikrein-6 antibody
    • Kallikrein6 antibody
    • KLK 6 antibody
    • Klk 7 antibody
    • KLK 9 antibody
    • Klk29 antibody
    • Klk6 antibody
    • KLK6_HUMAN antibody
    • Klk7 antibody
    • KLK9 antibody
    • MGC9355 antibody
    • mGK 1 antibody
    • mGK1 antibody
    • MSP antibody
    • Neurosin antibody
    • Protease M antibody
    • Protease serine 18 antibody
    • Protease serine 9 antibody
    • PRSS 18 antibody
    • PRSS 9 antibody
    • PRSS18 antibody
    • PRSS9 antibody
    • Serine protease 18 antibody
    • Serine protease 9 antibody
    • SP 59 antibody
    • SP59 antibody
    • Tissue kallikrein antibody
    • TK antibody
    • Zyme antibody
    see all

Anti-Kallikrein 6 antibody 画像

  • All lanes : Anti-Kallikrein 6 antibody (ab109295) at 2 µg/ml

    Lane 1 : Mouse Liver lysate (in RIPA buffer) without immunizing peptide
    Lane 2 : Mouse Liver lysate (in RIPA buffer) with immunizing peptide

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique

    Predicted band size : 27 kDa
    Observed band size : 22 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 48 kDa. We are unsure as to the identity of these extra bands.

Anti-Kallikrein 6 antibody (ab109295) 使用論文

ab109295 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab109295.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"