製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to KAL1
  • アプリケーション
    適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide of Human KAL1, conjugated to KLH.

  • ポジティブ・コントロール
    • Human skeletal muscle tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 20 - 40 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    May be an adhesion-like molecule with anti-protease activity.
  • 関連疾患
    Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1) [MIM:308700]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
  • 配列類似性
    Contains 4 fibronectin type-III domains.
    Contains 1 WAP domain.
  • 翻訳後修飾
    N-glycosylated.
  • 細胞内局在
    Cell surface.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Adhesion molecule-like X-linked antibody
    • ADMLX antibody
    • Anosmin-1 antibody
    • HHA antibody
    • KAL antibody
    • KAL1 antibody
    • KALIG 1 antibody
    • KALIG1 antibody
    • Kallmann syndrome 1 sequence (anosmin 1) antibody
    • Kallmann syndrome 1 sequence antibody
    • Kallmann syndrome interval gene 1 antibody
    • Kallmann syndrome protein antibody
    • KALM antibody
    • KALM_HUMAN antibody
    • KMS antibody
    • OTTHUMP00000022873 antibody
    see all

画像

  • ab115270, at 40 µg/ml, staining KAL1 in formalin fixed, paraffin embedded Human skeletal muscle tissue by Immunohistochemistry. After incubation with the primary antibody, slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

プロトコール

参考文献

ab115270 has not yet been referenced specifically in any publications.

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