製品の概要

  • 製品名Anti-Junctophilin-2 antibody
    Junctophilin-2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Junctophilin-2
  • 特異性Multiple isoforms of JPH2 are known to exist.
  • アプリケーション適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    A 17 amino acid peptide near the carboxy terminus of Human Junctophilin-2.

  • ポジティブ・コントロール
    • Human Heart and Skeletal Muscle. Mouse brain tissue lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab110056 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 75 kDa.
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum. Contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development.
  • 組織特異性Specifically expressed in skeletal muscle and heart.
  • 関連疾患Defects in JPH2 are the cause of cardiomyopathy familial hypertrophic type 17 (CMH17) [MIM:613873]. CMH17 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 配列類似性Belongs to the junctophilin family.
    Contains 8 MORN repeats.
  • ドメインThe MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.
  • 細胞内局在Cell membrane. Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ40969 antibody
    • JP-2 antibody
    • JP2 antibody
    • Jph2 antibody
    • JPH2_HUMAN antibody
    • Junctophilin 2 antibody
    • Junctophilin type 2 antibody
    • Junctophilin-2 antibody
    • OTTHUMP00000031651 antibody
    • OTTHUMP00000031652 antibody
    see all

Anti-Junctophilin-2 antibody 画像

  • Lane 1 : Anti-Junctophilin-2 antibody (ab110056) at 1 µg/ml
    Lane 2 : Anti-Junctophilin-2 antibody (ab110056) at 2 µg/ml

    Lane 1 : Mouse brain tissue lysate
    Lane 2 : Mouse brain tissue lysate


    Predicted band size : 75 kDa
  • ab110056 at 5 µg/ml staining Junctophilin-2 in Formalin-Fixed, Paraffin-Embedded Human Heart by Immunohistochemistry.
  • ab110056 at 5 µg/ml staining Junctophilin-2 in Formalin-Fixed, Paraffin-Embedded Human Skeletal Muscle by Immunohistochemistry.

Anti-Junctophilin-2 antibody (ab110056) 使用論文

ab110056 has not yet been referenced specifically in any publications.

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