Anti-Junctional Adhesion Molecule C 抗体 [19 H36] (ab16889)


  • 製品名
    Anti-Junctional Adhesion Molecule C antibody [19 H36]
    Junctional Adhesion Molecule C 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [19 H36] to Junctional Adhesion Molecule C
  • 由来種
  • アプリケーション
    適用あり: IP, Flow Cyt, IHC-Frmore details
    適用なし: IHC-P or WB
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    This information is considered to be commercially sensitive.

  • ポジティブ・コントロール
    • High endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells of the kidney



Our Abpromise guarantee covers the use of ab16889 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration.

ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.


IHC-Fr Use at an assay dependent concentration.
  • 追加情報
    Is unsuitable for IHC-P or WB.
  • ターゲット情報

    • 機能
      Participates in cell-cell adhesion. It is a counterreceptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
    • 組織特異性
      Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).
    • 関連疾患
      Defects in JAM3 are the cause of hemorrhagic destruction of the brain with subependymal calcification and cataracts (HDBSCC) [MIM:613730]. A syndrome characterized by congenital cataracts and severe brain abnormalities apparently resulting from hemorrhagic destruction of the brain tissue, including the cerebral white matter and basal ganglia. Patients manifest profound developmental delay, and other neurologic features included seizures, spasticity, and hyperreflexia. Brain imaging shows multifocal intraparenchymal hemorrhage with associated liquefaction and massive cystic degeneration, and calcification in the subependymal region and in brain tissue.
    • 配列類似性
      Belongs to the immunoglobulin superfamily.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 翻訳後修飾
      Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by proinflammatory factors.
    • 細胞内局在
      Cell membrane. Cell junction > desmosome. Secreted > extracellular space. In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitement of JAM3 to cell-cell contacts.
    • Information by UniProt
    • 参照データベース
    • 別名
      • FLJ14529 antibody
      • JAM 2 antibody
      • JAM 3 antibody
      • JAM C antibody
      • JAM-2 antibody
      • JAM-3 antibody
      • JAM-C antibody
      • JAM2 antibody
      • Jam3 antibody
      • JAM3_HUMAN antibody
      • JAMC antibody
      • Junctional adhesion molecule 3 antibody
      • Junctional adhesion molecule 3 precursor antibody
      • Junctional adhesion molecule C antibody
      see all


    ab16889 has not yet been referenced specifically in any publications.

    レビューと Q&A

    Thank you once again for your recent enquiries. I have investigated this case and have obtained the following information for you regarding out JAMC and JAM 2 antibodies. I can understand the confusion, and hope this will help. The SwissProt/Unipro...

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    I'm sorry you have been experiencing a problem with ab16889. As positive control for staining JAM-2 on frozen sections murine tissue of high endothelial venules of lymphoid organs can be used. Or lymphoendothelial cells and the endothelial cells of ...

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