機能May play a role in the processes of lymphocyte homing to secondary lymphoid organs.
組織特異性Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.
配列類似性Belongs to the immunoglobulin superfamily. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
細胞内局在Cell junction > tight junction. Cell membrane. Localized at tight junctions of both epithelial and endothelial cells.