製品の概要

  • 製品名Anti-JPH3 antibody
    JPH3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to JPH3
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide designed within N terminal amino acids 2-51 (SSGGRFNFD DGGSYCGGWE DGKAHGHGVC TGPKGQGEYT GSWSHGFEVL G) of Human JPH3 (NP_065706)

  • ポジティブ・コントロール
    • HepG2 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab81178 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 81 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/312500.

ターゲット情報

  • 機能Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic reticulum. May play an active role in certain neurons involved in motor coordination.
  • 組織特異性Specifically expressed in brain.
  • 関連疾患Defects in JPH3 are the cause of Huntington disease-like type 2 (HDL2) [MIM:606438]. Huntington disease (HD) is a neurodegenerative disorder resulting primarily from the loss of medium spiny projection neurons in the striatum, especially in the caudate nucleus, and, to a lesser extent, atrophy of mesencephalic and cortical structures. The typical clinical picture of HD combines familial adult onset chorea and subcortical dementia that usually begin during the fourth decade of life.
  • 配列類似性Belongs to the junctophilin family.
    Contains 8 MORN repeats.
  • ドメインThe MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.
  • 細胞内局在Cell membrane. Endoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • JP-3 antibody
    • JP3 antibody
    • JPH3 antibody
    • JPH3_HUMAN antibody
    • Junctophilin 3 antibody
    • Junctophilin type 3 antibody
    • Junctophilin-3 antibody
    • TNRC22 antibody
    • Trinucleotide repeat-containing gene 22 protein antibody
    see all

Anti-JPH3 antibody 画像

  • Anti-JPH3 antibody (ab81178) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 81 kDa
    Observed band size : 81 kDa
    Additional bands at : 60 kDa. We are unsure as to the identity of these extra bands.

Anti-JPH3 antibody (ab81178) 使用論文

ab81178 has not yet been referenced specifically in any publications.

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