製品の概要

  • 製品名Anti-JPH3 antibody
    JPH3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to JPH3
  • アプリケーション適用あり: ICC/IF, WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    A synthetic 18 amino acid peptide near the carboxy terminus of human JPH3 (protein accession number: NP_065706)

  • ポジティブ・コントロール
    • Daudi cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab79063 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 81 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic reticulum. May play an active role in certain neurons involved in motor coordination.
  • 組織特異性Specifically expressed in brain.
  • 関連疾患Defects in JPH3 are the cause of Huntington disease-like type 2 (HDL2) [MIM:606438]. Huntington disease (HD) is a neurodegenerative disorder resulting primarily from the loss of medium spiny projection neurons in the striatum, especially in the caudate nucleus, and, to a lesser extent, atrophy of mesencephalic and cortical structures. The typical clinical picture of HD combines familial adult onset chorea and subcortical dementia that usually begin during the fourth decade of life.
  • 配列類似性Belongs to the junctophilin family.
    Contains 8 MORN repeats.
  • ドメインThe MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.
  • 細胞内局在Cell membrane. Endoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • JP-3 antibody
    • JP3 antibody
    • JPH3 antibody
    • JPH3_HUMAN antibody
    • Junctophilin 3 antibody
    • Junctophilin type 3 antibody
    • Junctophilin-3 antibody
    • TNRC22 antibody
    • Trinucleotide repeat-containing gene 22 protein antibody
    see all

Anti-JPH3 antibody 画像

  • All lanes : Anti-JPH3 antibody (ab79063) at 1 µg/ml

    Lane 1 : Daudi cell lysate
    Lane 2 : Daudi cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 81 kDa
    Observed band size : 100 kDa (why is the actual band size different from the predicted?)
  • Immunofluorescence of JPH3 in Human Brain cells using ab79063 at 20 ug/ml.

Anti-JPH3 antibody (ab79063) 使用論文

ab79063 has not yet been referenced specifically in any publications.

Product Wall

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"