製品の概要

  • 製品名Anti-JNK3 antibody [2G12H3]
    JNK3 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2G12H3] to JNK3
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein corresponding to Human JNK3.

  • ポジティブ・コントロール
    • NIH3T3 cells

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab52267 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 37 kDa (predicted molecular weight: 53 kDa).
ELISA 1/10000.

ターゲット情報

  • 機能Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity.
  • 組織特異性Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
  • 関連疾患Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:606369]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.
  • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • ドメインThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻訳後修飾Dually phosphorylated on Thr-221 and Tyr-223, which activates the enzyme. Weakly autophosphorylated on threonine and tyrosine residues in vitro.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • c Jun kinase 3 antibody
    • c-Jun N-terminal kinase 3 antibody
    • cJun N terminal kinase 3 antibody
    • FLJ12099 antibody
    • FLJ33785 antibody
    • JNK3 alpha protein kinase antibody
    • JNK3 antibody
    • JNK3A antibody
    • MAP kinase 10 antibody
    • MAP kinase antibody
    • MAP kinase p49 3F12 antibody
    • MAPK 10 antibody
    • Mapk10 antibody
    • MGC50974 antibody
    • mitogen activated protein kinase 10 antibody
    • Mitogen-activated protein kinase 10 antibody
    • MK10_HUMAN antibody
    • p493F12 antibody
    • p54bSAPK antibody
    • PRKM10 antibody
    • protein kinase mitogen activated 10 antibody
    • SAPK1b antibody
    • Stress activated protein kinase 1b antibody
    • stress activated protein kinase beta antibody
    • Stress activated protein kinase JNK3 antibody
    • Stress-activated protein kinase JNK3 antibody
    see all

Anti-JNK3 antibody [2G12H3] 画像

  • All lanes : Anti-JNK3 antibody [2G12H3] (ab52267) at 1/500 dilution

    Lane 1 : recombinant MAPK10
    Lane 2 : NIH3T3 cells


    Predicted band size : 53 kDa
    Observed band of ~37kDa represents Isoform type 4.

Anti-JNK3 antibody [2G12H3] (ab52267) 使用論文

ab52267 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"