Anti-JNK1+JNK2 抗体 [279Q38] (ab37228)


  • 製品名Anti-JNK1+JNK2 antibody [279Q38]
    JNK1+JNK2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [279Q38] to JNK1+JNK2
  • 特異性ab37228 binds to both JNK1 and JNK2 proteins of molecular weight 46 and 54 kDa.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Recombinant fragment (Human) from JNKalpha1 expressed in E.coli.

  • ポジティブ・コントロール
    • Human Jurkat cells, mouse L929 cells and rat L6 cells.



Our Abpromise guarantee covers the use of ab37228 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報WB: Use at a concentration of 1 µg/ml. Predicted molecular weight:- JNK1: 45 Kda; JNK2: 54 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
      JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
    • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
      Contains 1 protein kinase domain.
    • ドメインThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    • 翻訳後修飾Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
    • Information by UniProt
    • 参照データベース
    • 別名
      • c jun N terminal kinase 2 antibody
      • c-Jun N-terminal kinase 1 antibody
      • cJun N terminal kinase 1 antibody
      • JNK 1 antibody
      • JNK 2 antibody
      • JNK-46 antibody
      • JNK2ALPHA antibody
      • JNK2BETA antibody
      • MAP kinase 8 antibody
      • MAP kinase 9 antibody
      • MAPK 8 antibody
      • mapk8 antibody
      • MAPK9 antibody
      • Mitogen activated protein kinase 8 antibody
      • Mitogen activated protein kinase 9 antibody
      • Mitogen-activated protein kinase 8 antibody
      • MK08_HUMAN antibody
      • PRKM 8 antibody
      • PRKM 9 antibody
      • Stress-activated protein kinase 1 antibody
      • Stress-activated protein kinase JNK1 antibody
      see all

    Anti-JNK1+JNK2 antibody [279Q38] 画像

    • Anti-JNK1+JNK2 antibody [279Q38] (ab37228) at 1 µg/ml + Cell extract of human Jurkat cells (10-30µg/lane total protein)

      Goat F(ab’)2 antimouse IgG, alkaline phosphatase conjugated antibody, at 1/2000 dilution

      Predicted band size : JNK1: 45 ; JNK2: 54 kDa
      Observed band size : 46,54 kDa (why is the actual band size different from the predicted?)

    Anti-JNK1+JNK2 antibody [279Q38] (ab37228) 使用論文

    ab37228 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

    I am sorry this product did not perform as stated on the datasheet and for the inconvenience this...

    Read More