Anti-JNK1 (phospho T183 + Y185) 抗体 (ab46821)
製品の概要
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製品名Anti-JNK1 (phospho T183 + Y185) antibody
JNK1 一次抗体 製品一覧 -
製品の詳細Chicken polyclonal to JNK1 (phospho T183 + Y185)
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由来種Chicken
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アプリケーション適用あり: WB, ELISA, ICC/IFmore details
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種交差性交差種: Mouse, Rat, Human
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免疫原
Synthetic peptide corresponding to Human JNK1 aa 180-188 (phospho T183 + Y185).
Sequence:FMM(pT)P(pY)VVT
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ポジティブ･コントロール
- PC12 cell extract.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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バッファーPreservative: None
Constituents: PBS -
Concentration information loading... -
精製度IgY fraction
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ポリ/モノポリクローナル
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アイソタイプIgY
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研究分野
関連製品
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab46821 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/1000 - 1/4000. Predicted molecular weight: 48 kDa. | |
| ELISA | 1/1000 - 1/4000. | |
| ICC/IF | 1/500 - 1/2000. |
ターゲット情報
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機能Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. -
配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Contains 1 protein kinase domain. -
ドメインThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
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翻訳後修飾Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
- Information by UniProt
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参照データベース
- Entrez Gene: 5599 Human
- Entrez Gene: 26419 Mouse
- Entrez Gene: 116554 Rat
- Omim: 601158 Human
- SwissProt: P45983 Human
- SwissProt: Q91Y86 Mouse
- SwissProt: P49185 Rat
- Unigene: 138211 Human
see all -
別名
- AI849689 antibody
- c Jun N terminal kinase 1 antibody
- C-JUN kinase 1 antibody
see all
参考文献
This product has been referenced in:
- Ma Y et al. Inhibiting tumor necrosis factor-a signaling attenuates postoperative cognitive dysfunction in aged rats. Mol Med Rep 12:3095-100 (2015). Read more (PubMed: 25955232) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"